3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

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Chemical Name:3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione
CAS No.:186385-77-3
Molecular Formula:C₂₅H₃₅ClF₄N₄O₄Si
Molecular Weight:595.109
Hs Code.:

3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

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Chemical Property of 3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

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Technology Process of 3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

There total 4 articles about 3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 186385-77-3
3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Cs₂CO₃; NMP

2: Nickel boride; aq. HCl / methanol / 60 °C

3: K₂CO₃ / bis-(2-methoxy-ethyl) ether / 220 °C

4: K₂CO₃; NaI / acetonitrile / Heating

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; nickel boride; potassium carbonate; caesium carbonate; sodium iodide; In methanol; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 186386-90-3
4-fluoro-2-(2,2,2-trifluoroethoxy)aniline

: 186385-77-3
3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / bis-(2-methoxy-ethyl) ether / 220 °C

2: K₂CO₃; NaI / acetonitrile / Heating

With potassium carbonate; sodium iodide; In diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 246264-85-7
1-SEM-5-chlorouracil

: 186385-77-3
3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)-phenyl]piperazin-1-yl}propyl)-5-chloro-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: K₂CO₃; NaI / acetonitrile / Heating

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(03)00305-6