D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol

Base Information

• Chemical Name: D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol
• CAS No.: 404351-01-5
• Molecular Formula: C₃₆H₅₂Cl₃N₃O₇
• Molecular Weight: 745.184
• Mol file: 404351-01-5.mol

Synonyms:

Chemical Property of D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol

There total 1 articles about D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

chloral (75-87-6) + dicyclohexyl-carbodiimide (538-75-0) + L-1-O-benzyl-2-O-methyl-chiro-inositol (402832-38-6) → L-4-O-benzyl-3-O-1,2-O-(2,2,2-trichloroethylidene)-3-O-cyclohexylcarbamoyl-5-O-methyl-muco-inositol (402724-04-3) + L-1-O-benzyl-6-O-cyclohexylcarbamoyl-3-O-formyl-2-O-methyl-4,5-O-trichloroethylidene-muco-inositol (402724-06-5) + D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol (404351-01-5)

Guidance literature:

In dichloromethane; for 8h; Heating;

DOI:10.1016/S0040-4039(01)01899-8

Reference yield:

D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol (404351-01-5) → D-1,2-O-(2,2,2-trichloroethylidene)-3-cyclohexylamino-3-deoxy-chiro-inositol

Guidance literature:

With hydrogen iodide; In water; for 2h; Heating;

DOI:10.1016/j.carres.2004.11.031

Reference yield:

D-2-O-benzyl-3-O-cyclohexylcarbamoyl-4-(N,N'-dicyclohexylureido)-4-deoxy-1-O-methyl-5,6-O-trichloroethylidene-chiro-inositol (404351-01-5) → D-4,5,6-tri-O-benzoyl-3-cyclohexylamino-3-deoxy-1,2-O-(2,2,2-trichloroethylidene)-chiro-inositol

Guidance literature:

Multi-step reaction with 2 steps

1: HI / H₂O / 2 h / Heating

2: 44 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; hydrogen iodide; In dichloromethane; water;

DOI:10.1016/j.carres.2004.11.031

upstream raw materials:

chloral

dicyclohexyl-carbodiimide

L-1-O-benzyl-2-O-methyl-chiro-inositol