5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

Base Information

Chemical Name:5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide
CAS No.:425641-98-1
Molecular Formula:C₂₅H₄₁N₃O₆SSi
Molecular Weight:539.769
Hs Code.:

5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

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Chemical Property of 5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

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Technology Process of 5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

There total 1 articles about 5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129378-52-5
2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide

: 103795-12-6
(R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

: 425641-98-1
5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

: 5-[(1R,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

Guidance literature:: 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide; With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

(R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;
DOI:10.1002/1099-0690(200202)2002:4<702::AID-EJOC702>3.0.CO;2-Y

Reference yield:

: 100-39-0
benzyl bromide

: 425641-98-1
5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

: 5-[(1S,2S)-1,2-Bis-benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 40 ℃; for 15h;
DOI:10.1002/1099-0690(200202)2002:4<702::AID-EJOC702>3.0.CO;2-Y

Reference yield:

: 425641-98-1
5-[(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyl)-imidazole-1-sulfonic acid dimethylamide

: 425642-03-1
(2R,3R,4S)-3,4-Bis-benzyloxy-4-(1H-imidazol-4-yl)-butane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: NaH; Bu₄NI / tetrahydrofuran / 15 h / 40 °C

2: 1.74 g / HCl / H₂O; tetrahydrofuran / 14 h / 45 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; water;
DOI:10.1002/1099-0690(200202)2002:4<702::AID-EJOC702>3.0.CO;2-Y