(2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

Base Information

Chemical Name:(2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid
CAS No.:32222-47-2
Molecular Formula:C₈H₇FO₃
Molecular Weight:170.14
Hs Code.:

Synonyms:

Suppliers and Price of (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

There total 25 articles about (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 773837-37-9
sodium cyanide

: 456-48-4
3-Fluorobenzaldehyde

: 32222-47-2,52923-24-7,52950-14-8,395-05-1
2-(3-fluorophenyl)-2-hydroxyacetic acid

Guidance literature:: sodium cyanide; 3-Fluorobenzaldehyde; With benzyltrimethylammonium chloride; In diethyl ether; at 0 ℃; for 0.0833333h;

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 16h;

Reference yield: 32.0%

: 32222-47-2,52923-24-7,52950-14-8,395-05-1
2-(3-fluorophenyl)-2-hydroxyacetic acid

: 395-05-1,52923-24-7,52950-14-8,32222-47-2
(2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

Guidance literature:: With vinyl acetate; In tert-butyl methyl ether; at 26 ℃; for 90h; Enzymatic reaction;

Reference yield:

: 456-48-4
3-Fluorobenzaldehyde

: 32222-47-2,52923-24-7,52950-14-8,395-05-1
2-(3-fluorophenyl)-2-hydroxyacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 10percent aq. H₂SO₄ / ethanol / 7.9 °C

2: conc. aq. HCl / 19 h / Ambient temperature

With hydrogenchloride; sulfuric acid; In ethanol;
DOI:10.1107/S0108768193010766