methyl 4-[2-(1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl ether

Base Information

Chemical Name:methyl 4-[2-(1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl ether
CAS No.:128433-02-3
Molecular Formula:C₁₃H₁₁N₃OS
Molecular Weight:257.316
Hs Code.:
DSSTox Substance ID:DTXSID301325650
ChEMBL ID:CHEMBL1341232

Synonyms:128433-02-3;methyl 4-[2-(1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl ether;4-(4-methoxyphenyl)-2-pyrazol-1-yl-1,3-thiazole;4-(4-methoxyphenyl)-2-(1H-pyrazol-1-yl)-1,3-thiazole;MLS001165950;CHEMBL1341232;DTXSID301325650;HMS2859I09;MFCD03102607;AKOS005099056;SMR000550211;6T-0801

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-[2-(1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl ether

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:257.06228316
Heavy Atom Count:18
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CSC(=N2)N3C=CC=N3

Technology Process of methyl 4-[2-(1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl ether

There total 1 articles about methyl 4-[2-(1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4871-25-4
2-hydrazino-4-(4-methoxy-phenyl)-thiazole

: 102-52-3
malonaldehydebis(dimethylacetal)

: 128433-02-3
4-(4-Methoxy-phenyl)-2-pyrazol-1-yl-thiazole

Guidance literature:: With hydrogenchloride; In ethanol; for 6h; Heating;

Reference yield:

: 128433-02-3
4-(4-Methoxy-phenyl)-2-pyrazol-1-yl-thiazole

: 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 12 h / Heating

2: sodium iodide; hydroxylamine / N,N-dimethyl-formamide / Reflux

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 72 h / Reflux

With sodium azide; hydroxylamine; ammonium chloride; trifluoroacetic acid; sodium iodide; In N,N-dimethyl-formamide; 1: |Duff Aldehyde Synthesis;
DOI:10.1016/j.bmc.2015.08.002

Reference yield:

: 128433-02-3
4-(4-Methoxy-phenyl)-2-pyrazol-1-yl-thiazole

: C₁₄H₁₀N₄OS

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 12 h / Heating

2: sodium iodide; hydroxylamine / N,N-dimethyl-formamide / Reflux

With hydroxylamine; trifluoroacetic acid; sodium iodide; In N,N-dimethyl-formamide; 1: |Duff Aldehyde Synthesis;
DOI:10.1016/j.bmc.2015.08.002