5-Chloro-2-(β-hydroxyethylaminoacetylamino)-2'-chlorobenzophenone

Base Information

• Chemical Name: 5-Chloro-2-(β-hydroxyethylaminoacetylamino)-2'-chlorobenzophenone
• CAS No.: 24234-92-2
• Molecular Formula: C₁₇H₁₆Cl₂N₂O₃
• Molecular Weight: 367.232
• Mol file: 24234-92-2.mol

Synonyms:

Chemical Property of 5-Chloro-2-(β-hydroxyethylaminoacetylamino)-2'-chlorobenzophenone

Chemical Property:

• Melting Point: 106-109°C
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-?[4-?Chloro-?2-?(2-?chlorobenzoyl)?phenyl]?-?2-?[(2-?hydroxyethyl)?amino]?acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-?[4-?Chloro-?2-?(2-?chlorobenzoyl)?phenyl]?-?2-?[(2-?hydroxyethyl)?amino]?acetamide is an impurity of Cloxazolam (C587475). Cyclization of N-?[4-?Chloro-?2-?(2-?chlorobenzoyl)?phenyl]?-?2-?[(2-?hydroxyethyl)?amino]?acetamide can produce Cloxazolam. Cloxazolam is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. Cloxazolam is metabolized into the active metabolite Delorezepam (D230675).

Technology Process of 5-Chloro-2-(β-hydroxyethylaminoacetylamino)-2'-chlorobenzophenone

There total 3 articles about 5-Chloro-2-(β-hydroxyethylaminoacetylamino)-2'-chlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cloxazolam (24166-13-0,158251-57-1) → N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide (24234-92-2)

Guidance literature:

With water; In hydrogenchloride; at 37 - 56 ℃; Rate constant; Thermodynamic data;

DOI:10.1248/cpb.34.320

Reference yield:

ethanolamine (141-43-5) + 2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone (5504-92-7) → N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide (24234-92-2)

Guidance literature:

DOI:10.1021/jm00288a015

Reference yield:

→ N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide (24234-92-2)

Guidance literature:

o.a. Beisp. 31;

upstream raw materials:

ethanolamine

2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone

cloxazolam

Downstream raw materials:

10-chloro-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

10-chloro-11b-(2-chloro-phenyl)-7-ethyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

cloxazolam

Refernces

• 1、 Miyadera,Terada,Fukunaga,Kawano,Kamioka,Tamura,Takagi,Tachikawa. "Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo[6,7]-1,4-diazepino[5,4-b]oxazole derivatives and analogs.". . p. 520 - 526. Retrieved 2007/10/08.