(R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

• Chemical Name: (R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
• CAS No.: 120040-99-5
• Molecular Formula: C₃₆H₆₁NO₄S
• Molecular Weight: 603.951
• Mol file: 120040-99-5.mol

Synonyms:

Chemical Property of (R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 1 articles about (R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H17Li (120040-93-9) + (1S,2R,4R)-1-(N,N-dicyclohexylaminosulfonylmethyl)-7,7-dimethylbicyclo<2.2.1>heptan-2-yl crotonate (104898-08-0) → (R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (120040-99-5)

Guidance literature:

Product distribution; multistep reaction: investigation of enantioselectivity with var. reagents;

DOI:10.1016/S0040-4020(01)86156-1

Reference yield:

(R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (120040-99-5) → (-)-10-dicyclohexylsulfamoyl-D-isoborneol (96303-88-7) + (3S,6R)-3-methyl-6-(1-methylethenyl)-9-decen-1-ol (71256-76-3) + (3R,6R)-6-Isopropenyl-3-methyl-dec-9-en-1-ol (120040-96-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature; addition 0 deg C;

DOI:10.1016/S0040-4020(01)86156-1

Reference yield:

(R)-6-Isopropenyl-3-methyl-dec-9-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (120040-99-5) + acetyl chloride (75-36-5) → (-)-10-dicyclohexylsulfamoyl-D-isoborneol (96303-88-7) + (3S,6R)-3-methyl-6-(1-methylethenyl)-9-decen-1-yl acetate (67601-06-3) + Acetic acid (3R,6R)-6-isopropenyl-3-methyl-dec-9-enyl ester (67601-04-1)

Guidance literature:

With lithium aluminium tetrahydride; triethylamine; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) ether, 0 deg C to room t., 30 min, 2.) ether, 0 deg C to room t., 2 h;

DOI:10.1016/S0040-4020(01)86156-1

upstream raw materials:

C₁₀H₁₇Li

(1S,2R,4R)-1-(N,N-dicyclohexylaminosulfonylmethyl)-7,7-dimethylbicyclo<2.2.1>heptan-2-yl crotonate

Downstream raw materials:

(-)-10-dicyclohexylsulfamoyl-D-isoborneol

(3S,6R)-3-methyl-6-(1-methylethenyl)-9-decen-1-ol

(3R,6R)-6-Isopropenyl-3-methyl-dec-9-en-1-ol

(3S,6R)-3-methyl-6-(1-methylethenyl)-9-decen-1-yl acetate