Technology Process of (2S,4R,5S,6R)-N-tert-butoxycarbonyl-2-methyl-5-O-benzyl-6,7-O-isopropylidene-2,3-dideoxy-heptono-1,4-lactam
There total 6 articles about (2S,4R,5S,6R)-N-tert-butoxycarbonyl-2-methyl-5-O-benzyl-6,7-O-isopropylidene-2,3-dideoxy-heptono-1,4-lactam which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: DMAP / acetonitrile / Ambient temperature
2: 2,6-lutidine / CH2Cl2 / Ambient temperature
3: 80 percent / SnCl4 / diethyl ether; CH2Cl2 / 3 h / -85 °C
4: 92 percent / H2, NaOAc / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature
5: 88 percent / Ag2O / tetrahydrofuran / 5 h / Ambient temperature
6: 1.) lithium hexamethyldisalazide (LiHMDS) / 1.) THF, -80 deg C, 1 h, 2.) a.) -80 deg C, 1 h, b.) RT, 1 h
With
2,6-dimethylpyridine; dmap; hydrogen; sodium acetate; tin(IV) chloride; silver(l) oxide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/S0957-4166(00)86037-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2,6-lutidine / CH2Cl2 / Ambient temperature
2: 80 percent / SnCl4 / diethyl ether; CH2Cl2 / 3 h / -85 °C
3: 92 percent / H2, NaOAc / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature
4: 88 percent / Ag2O / tetrahydrofuran / 5 h / Ambient temperature
5: 1.) lithium hexamethyldisalazide (LiHMDS) / 1.) THF, -80 deg C, 1 h, 2.) a.) -80 deg C, 1 h, b.) RT, 1 h
With
2,6-dimethylpyridine; hydrogen; sodium acetate; tin(IV) chloride; silver(l) oxide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0957-4166(00)86037-1
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / H2, NaOAc / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature
2: 88 percent / Ag2O / tetrahydrofuran / 5 h / Ambient temperature
3: 1.) lithium hexamethyldisalazide (LiHMDS) / 1.) THF, -80 deg C, 1 h, 2.) a.) -80 deg C, 1 h, b.) RT, 1 h
With
hydrogen; sodium acetate; silver(l) oxide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran;
DOI:10.1016/S0957-4166(00)86037-1
