(4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ⁶-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone

Base Information

• Chemical Name: (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ⁶-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone
• CAS No.: 508183-73-1
• Molecular Formula: C₃₀H₃₄N₄O₅S
• Molecular Weight: 562.69

Synonyms:

Chemical Property of (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ⁶-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ⁶-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone

There total 2 articles about (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ⁶-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-Methoxyphenyl)piperazine (35386-24-4) → (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ6-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone (508183-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: EtONa / ethanol / 15 h / Heating

With sodium ethanolate; In ethanol;

DOI:10.1016/S0014-827X(02)01267-3

Reference yield:

2H-3-benzoyl-4-hydroxy-5,7-dimethylpyrido<3,2-e>-1,2-thiazine-1,1-dioxide (108586-75-0) + 1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine (21279-77-6) → (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ6-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone (508183-73-1)

Guidance literature:

With sodium ethanolate; In ethanol; for 15h; Heating;

DOI:10.1016/S0014-827X(02)01267-3

Reference yield: 46.0%

N-methyl-ethane-1,2-diamine (109-81-9) + (4-hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-1,1-dioxo-1,2-dihydro-1λ6-pyrido[3,2-e][1,2]thiazin-3-yl)-phenyl-methanone (508183-73-1) → 2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5,7-dimethyl-3-[(2-methylamino-ethylamino)-phenyl-methylene]-1,1-dioxo-2,3-dihydro-1H-1λ6-pyrido[3,2-e][1,2]thiazin-4-one

Guidance literature:

In ethanol; for 15h; Heating;

upstream raw materials:

2H-3-benzoyl-4-hydroxy-5,7-dimethylpyrido<3,2-e>-1,2-thiazine-1,1-dioxide

1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine

1-(2-Methoxyphenyl)piperazine

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