(R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

Base Information

Chemical Name:(R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid
CAS No.:1648953-38-1
Molecular Formula:C₁₉H₂₅NO₃
Molecular Weight:315.412
Hs Code.:

Synonyms:

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Chemical Property of (R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

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Technology Process of (R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

There total 4 articles about (R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213681-40-4
(R)-2-benzylsuccinic acid

: 1648953-38-1
(R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane; water / 0.17 h / pH 13

2: acetic anhydride / dichloromethane / 3 h / 25 - 48 °C / Inert atmosphere

3: toluene / 0.5 h / 45 - 47 °C / Inert atmosphere

With acetic anhydride; sodium hydroxide; In dichloromethane; water; toluene;
DOI:10.14233/ajchem.2014.16137

Reference yield:

: 36092-42-9,884-33-3
2-benzylsuccinic acid

: 1648953-38-1
(R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 5 h / 28 - 30 °C / Inert atmosphere; Resolution of racemate

2: sodium hydroxide / dichloromethane; water / 0.17 h / pH 13

3: acetic anhydride / dichloromethane / 3 h / 25 - 48 °C / Inert atmosphere

4: toluene / 0.5 h / 45 - 47 °C / Inert atmosphere

With acetic anhydride; sodium hydroxide; In ethanol; dichloromethane; water; toluene;
DOI:10.14233/ajchem.2014.16137

Reference yield:

: 21307-97-1,884-33-3
(R)-2-benzylsuccinic acid

: 1648953-38-1
(R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / dichloromethane / 3 h / 25 - 48 °C / Inert atmosphere

2: toluene / 0.5 h / 45 - 47 °C / Inert atmosphere

With acetic anhydride; In dichloromethane; toluene;
DOI:10.14233/ajchem.2014.16137