(R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane

Base Information

• Chemical Name: (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane
• CAS No.: 1353566-53-6
• Molecular Formula: C₃₄H₆₄O₂Si₂
• Molecular Weight: 561.052
• Mol file: 1353566-53-6.mol

Synonyms:

Chemical Property of (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane

There total 5 articles about (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-triethyl((2-methyloxiran-2-yl)methoxy)silane (1353566-46-7) → (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane (1353566-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide / tetrahydrofuran / -45 - -30 °C / Inert atmosphere

1.2: 18 h / -30 - 0 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol203185f

Reference yield:

1 ,6-dibromohexane (629-03-8) → (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane (1353566-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / Inert atmosphere

1.2: 16 h / -10 - 20 °C / Inert atmosphere

2.1: magnesium / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 18 h / 0 - 4 °C / Inert atmosphere

3.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -25 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With tert.-butyl lithium; magnesium; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;

DOI:10.1021/ol203185f

Reference yield:

9-phenyl-1-bromononane (103602-67-1) → (R)-3,3,8,8-tetraethyl-5-methyl-5-(2-methylene-12-phenyldodecyl)-4,7-dioxa-3,8-disiladecane (1353566-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 18 h / 0 - 4 °C / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -25 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With tert.-butyl lithium; magnesium; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;

DOI:10.1021/ol203185f

upstream raw materials:

1 ,6-dibromohexane

(R)-triethyl((2-methyloxiran-2-yl)methoxy)silane

(11-bromododec-11-en-1-yl)benzene

1-Bromo-3-phenylpropane

Downstream raw materials:

(R)-2-methyl-4-methylene-14-phenyl-2-((triethylsilyl)oxy)tetradecan-1-ol

(R)-2-methyl-4-methylene-14-phenyl-2-((triethylsilyl)oxy)tetradecanal

(2R,3R)-2-methyl-2-(2-methylene-12-phenyldodecyl)-5-oxotetrahydrofuran-3-yl acetate

C₃₅H₆₄O₄Si₂

Refernces