(1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane

Base Information

Chemical Name:(1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane
CAS No.:223394-06-7
Molecular Formula:C₂₅H₂₅NO₂
Molecular Weight:371.479
Hs Code.:

(1S,2S)-3-<N-(benzoyl)piperidin-4-yl>-1,2-epoxy-1-(nahth-1-yl)propane

Synonyms:

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Chemical Property of (1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane

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Technology Process of (1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane

There total 9 articles about (1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 223394-06-7
(1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂, conc. HCl / Pt/C / H₂O / 264 h / Ambient temperature

2: 98 percent / 4M NaOH / Ambient temperature

3: (COCl)2, DMSO, Et₃N / tetrahydrofuran / 0.5 h / -35 - 20 °C

4: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) THF, -78 deg C -> room temperature, 2 h

5: PhSSPh / CHCl₃ / 240 h / Irradiation

6: 93 percent / Ad-mix-α, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

7: 1.) CH₃C(OCH₃)3, TMSCL, 2.) K₂CO₃ / 1.) CH₂Cl₂, room temperature, 2 h, 2.) MeOH, room temperature, 1 h

With hydrogenchloride; Trimethyl orthoacetate; sodium hydroxide; AD-mix-α; n-butyllithium; chloro-trimethyl-silane; oxalyl dichloride; methanesulfonamide; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; diphenyldisulfane; platinum on activated charcoal; In tetrahydrofuran; chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2

Reference yield:

: 39171-65-8
bromo(naphthalen-1-ylmethyl)triphenyl-λ5-phosphane

: 223394-06-7
(1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) THF, -78 deg C -> room temperature, 2 h

2: PhSSPh / CHCl₃ / 240 h / Irradiation

3: 93 percent / Ad-mix-α, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

4: 1.) CH₃C(OCH₃)3, TMSCL, 2.) K₂CO₃ / 1.) CH₂Cl₂, room temperature, 2 h, 2.) MeOH, room temperature, 1 h

With Trimethyl orthoacetate; AD-mix-α; n-butyllithium; chloro-trimethyl-silane; methanesulfonamide; potassium carbonate; diphenyldisulfane; In chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2

Reference yield:

: 152902-80-2
(4-(2-hydroxyethyl)piperidin-1-yl)(phenyl)methanone

: 223394-06-7
(1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2, DMSO, Et₃N / tetrahydrofuran / 0.5 h / -35 - 20 °C

2: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) THF, -78 deg C -> room temperature, 2 h

3: PhSSPh / CHCl₃ / 240 h / Irradiation

4: 93 percent / Ad-mix-α, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

5: 1.) CH₃C(OCH₃)3, TMSCL, 2.) K₂CO₃ / 1.) CH₂Cl₂, room temperature, 2 h, 2.) MeOH, room temperature, 1 h

With Trimethyl orthoacetate; AD-mix-α; n-butyllithium; chloro-trimethyl-silane; oxalyl dichloride; methanesulfonamide; potassium carbonate; dimethyl sulfoxide; triethylamine; diphenyldisulfane; In tetrahydrofuran; chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2