152902-80-2

Upstream product

• 622-26-4 4-(2-Hydroxyethyl)piperidine 
• 98-88-4 benzoyl chloride 
• 28356-58-3 pyridine-4-acetic acid 
• 5344-27-4 4-(2-hydroxyethyl)pyridine 
• 54108-67-7 N-benzoyl-4-(carbethoxymethyl)piperidine 

Downstream Products

• 223393-97-3 2-ethanal 
• 168467-95-6 (4-(2-chloroethyl)piperidin-1-yl)phenylmethanone 
• 189177-06-8 (2R,1'S)-2-(1-hydroxy-1-phenyl)methyl-1-azabicyclo[2.2.2]octane 
• 189177-29-5 2-(1-hydroxy-1-phenyl)methyl-1-azabicyclo[2.2.2]octane 
• 223394-05-6 (1S,2S)-3--1,2-dihydroxy-1-(naphth-1-yl)propane 
• 223394-06-7 (1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane 
• 223394-04-5 E-3--1-(naphth-1-yl)prop-1-ene 
• 223394-03-4 [4-((E)-3-Naphthalen-1-yl-allyl)-piperidin-1-yl]-phenyl-methanone 
• 223394-19-2 (2S,3S)-4--2,3-epoxy-1-methoxybutane 
• 223394-18-1 (2S,3S)-4--2,3-epoxybutan-1-ol 
• 223394-17-0 4-<(N-benzoyl)piperidin-4-yl>but-2-en-1-ol 
• 189177-06-8 (2R,1'S)-2-(1-phenyl-1-hydroxy)methyl-1-azabicyclo<2.2.2>octane 
• 189177-29-5 (2R,1'R)-2-(1-hydroxy-1-phenyl)methyl-1-azabicyclo<2.2.2>octane 
• 189177-28-4 (2S,1'S)-2-(1-hydroxy-1-phenyl)methyl-1-azabicyclo<2.2.2>octane 

Relevant academic research and scientific papers

Nitrogenous heterocyclic compound with nematocidal activity, preparation method and application thereof

The invention relates to a nitrogenous heterocyclic compound with nematocidal activity, a preparation method and application thereof. Specifically, the invention discloses a compound with a formula (I) or an optical isomer, cis-trans isomer or acceptable salt in agricultural pharmacology and a preparation method thereof. The invention further discloses an agricultural composition containing the compound and application thereof. The compound has excellent nematocidal activity.

Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): High affinity ligands for the dopamine transporter

A series of 4-[2-[bis(4-fluorophenyl)methoxy]ethylpiperidines were examined for their ability to bind to the dopamine transporter (DAT), the norepinephrine transporter, and the serotonin transporter (SERT). In particular, the role of the N-substituent on

Asymmetric approaches to 2-hydroxymethylquinuclidine derivatives

Highly enantio- and diastereoselective routes to 2- hydroxymethylquinuclidines have been developed. Key steps involve the use of Sharpless dihydroxylation or Sharpless epoxidation to introduce the asymmetry with high stereocontrol, and formation of the quinuclidine ring systems via cyclisation of epoxy amines.

Therapeutic agents

Compounds of formula I STR1 and pharmaceutically acceptable salts thereof in which R1, R2 and R3 independently represent hydrogen, hydroxy, halo, alkyl or alkoxy; ALK1 represents a C2-6 alkylene chain optionally substituted by one or more C1-2 alkyl groups; Y represents a piperidine ring which is attached through nitrogen to ALK1 ; R4 represents hydrogen or a C1-4 alkyl group; the broken line in --- represents a bond, or is absent and the free valency on Y is taken up by hydrogen and the free valency on CR4 is taken up by hydrogen or a C1-4 alkyl group; ALK2 is absent or represents a C1-4 alkylene chain optionally substituted by one or more C1-2 alkyl groups; and R5 and R6 independently represent hydrogen, alkyl, phenyl, alkyl (optionally substituted) or R5 and R6 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring (with a proviso); are disclosed which are antiinflammatory, antiallergic and immunomodulatory agents. Compositions containing these compounds and processes to prepare these compounds are also disclosed.

Azolyl-cyclic amine derivates with immunomodulatory activity

A compound of the formula (I), STR1 as defined in the specification, having immunomodulatory activity, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compound, and processes to make and to use the compound are described.

Enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine

An enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine is reported. Key steps involve the use of the Sharpless dihydroxylation protocol to induce asymmetry, and stereodivergent cyclisations of the resulting diol to form the quinuclidine ring.

Novel piperidine σ receptor ligands as potential antipsychotic drugs

σ receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel disubstituted piperidine σ ligands, which have little or no affinity for dopamine D2 receptors. Selectivity for σ sites over dopamine D2 or serotonin 5-HT2 receptors appears to be governed by the chemical nature of the piperidine nitrogen substituent, its distance from the basic nitrogen, and its orientation relative to the other piperidine substituent. Several of these compounds have good oral potency in some animal models used to evaluate potential antipsychotic drugs. The N-cyclopropylmethyl ketones and ethers (e.g. 6i (DuP 734), 6q, 18a, and 18n) have the best in vivo potency. Compounds 6i (DuP 734) and 6q did not cause catalepsy in the rat, even at very high doses. On the basis of the pharmacology profiles of these σ ligands, we propose these compounds may be effective antipsychotic drugs, which do not induce extrapyramidal side effects or tardive dyskinesia.