Technology Process of (R)-2-Ethoxy-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid benzyl ester
There total 6 articles about (R)-2-Ethoxy-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Boc2O, pyridine, NH4HCO3 / dimethylformamide / Ambient temperature
2: n-BuLi / tetrahydrofuran / -70 °C
3: acetonitrile / Ambient temperature
4: 76 percent / Dowex 2X8-400 (hydroxide form) / acetonitrile / Ambient temperature
5: 1.) 4M HCl, 2.) NaHCO3 / 1.) dioxane, room temperature, 4 h, 2.) MeOH
6: 1.) LiBH4, 2.) conc.H2SO4 / 1.) THF, -20 deg C, 2.) room temperature
With
pyridine; hydrogenchloride; lithium borohydride; n-butyllithium; di-tert-butyl dicarbonate; Dowex 2X8-400 (hydroxide form); sulfuric acid; sodium hydrogencarbonate; ammonium bicarbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo990306s
- Guidance literature:
-
Multi-step reaction with 5 steps
1: n-BuLi / tetrahydrofuran / -70 °C
2: acetonitrile / Ambient temperature
3: 76 percent / Dowex 2X8-400 (hydroxide form) / acetonitrile / Ambient temperature
4: 1.) 4M HCl, 2.) NaHCO3 / 1.) dioxane, room temperature, 4 h, 2.) MeOH
5: 1.) LiBH4, 2.) conc.H2SO4 / 1.) THF, -20 deg C, 2.) room temperature
With
hydrogenchloride; lithium borohydride; n-butyllithium; Dowex 2X8-400 (hydroxide form); sulfuric acid; sodium hydrogencarbonate;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/jo990306s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetonitrile / Ambient temperature
2: 76 percent / Dowex 2X8-400 (hydroxide form) / acetonitrile / Ambient temperature
3: 1.) 4M HCl, 2.) NaHCO3 / 1.) dioxane, room temperature, 4 h, 2.) MeOH
4: 1.) LiBH4, 2.) conc.H2SO4 / 1.) THF, -20 deg C, 2.) room temperature
With
hydrogenchloride; lithium borohydride; Dowex 2X8-400 (hydroxide form); sulfuric acid; sodium hydrogencarbonate;
In
acetonitrile;
DOI:10.1021/jo990306s
