C₂₁H₃₀N₂O₂

Base Information

• Chemical Name: C₂₁H₃₀N₂O₂
• CAS No.: 2452222-13-6
• Molecular Formula: C₂₁H₃₀N₂O₂
• Molecular Weight: 342.481
• Mol file: 2452222-13-6.mol

Synonyms:

Chemical Property of C₂₁H₃₀N₂O₂

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₃₀N₂O₂

There total 8 articles about C₂₁H₃₀N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl bromide (100-39-0) + 1,1‐bis[(4S)‐4‐isopropyl‐4,5‐dihydrooxazol‐2‐yl]ethane (499786-37-7) → (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4-isopropyl-4,5-dihydrooxazole) (698350-53-7,2452222-13-6)

Guidance literature:

1,1‐bis[(4S)‐4‐isopropyl‐4,5‐dihydrooxazol‐2‐yl]ethane; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.200800536

Reference yield:

(R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) → C21H30N2O2 (2452222-13-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / 140 °C / Inert atmosphere; Schlenk technique

2.1: triethylamine / dichloromethane / Inert atmosphere; Schlenk technique

2.2: Inert atmosphere; Schlenk technique

3.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere; Schlenk technique

3.2: 5 h / Inert atmosphere; Schlenk technique; Reflux

4.1: n-butyllithium / tetrahydrofuran / Inert atmosphere; Schlenk technique

4.2: Inert atmosphere; Schlenk technique

With n-butyllithium; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1039/d0cc01716g

Reference yield:

C14H28N2O4 → C21H30N2O2 (2452222-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / Inert atmosphere; Schlenk technique

1.2: Inert atmosphere; Schlenk technique

2.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere; Schlenk technique

2.2: 5 h / Inert atmosphere; Schlenk technique; Reflux

3.1: n-butyllithium / tetrahydrofuran / Inert atmosphere; Schlenk technique

3.2: Inert atmosphere; Schlenk technique

With n-butyllithium; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1039/d0cc01716g

upstream raw materials:

benzyl bromide

1,1‐bis[(4S)‐4‐isopropyl‐4,5‐dihydrooxazol‐2‐yl]ethane

(S)-valinol

(R)-2-amino-3-methylbutanol