5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid

Base Information

Chemical Name:5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid
CAS No.:1253569-20-8
Molecular Formula:C₈H₉BFNO₄
Molecular Weight:212.973
Hs Code.:

Synonyms:

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Chemical Property of 5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid

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Technology Process of 5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid

There total 4 articles about 5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5419-55-6
Triisopropyl borate

: 1034467-47-4
5-(1,3-dioxolan-2-yl)-2-fluoropyridine

: 1253569-20-8
5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid

Guidance literature:: 5-(1,3-dioxolan-2-yl)-2-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; for 1.58333h; Inert atmosphere; Cooling with acetone-dry ice;

Triisopropyl borate; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; n-heptane; ethylbenzene; water;

Reference yield:

: C₁₄H₂₁BFNO₄

: 1253569-20-8
5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid

Guidance literature:: C₁₄H₂₁BFNO₄; With sodium hydroxide; In tetrahydrofuran; n-heptane; ethylbenzene; water; at 22 ℃;

With hydrogenchloride; In water; pH=5;
DOI:10.1021/jm300184s

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1253569-20-8
5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 0.75 h / 120 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1.58 h / Inert atmosphere; Cooling with acetone-dry ice

2.2: 4.5 h / 22 °C / Inert atmosphere; Cooling with acetone-dry ice

3.1: sodium hydroxide / tetrahydrofuran; n-heptane; ethylbenzene; water / 22 °C

3.2: pH 5

With toluene-4-sulfonic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; water; toluene;
DOI:10.1021/jm300184s