2-(aminomethyl)-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2-(aminomethyl)-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester
• CAS No.: 1239320-01-4
• Molecular Formula: C₁₃H₂₄N₂O₂
• Molecular Weight: 240.346
• Mol file: 1239320-01-4.mol

Synonyms:

Chemical Property of 2-(aminomethyl)-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-Aminomethyl-6-Boc-6-Aza-spiro[3.4]octane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(aminomethyl)-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester

There total 4 articles about 2-(aminomethyl)-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate (1374658-99-7) → tert-butyl 2-aminomethyl-6-azaspiro[3.4]octane-6-carboxylate (1239320-01-4)

Guidance literature:

With sodium hydroxide; Raney Nickel; In ethanol; dichloromethane;

Reference yield:

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester (1239319-91-5) → tert-butyl 2-aminomethyl-6-azaspiro[3.4]octane-6-carboxylate (1239320-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1.5 h / 20 °C

2: dimethyl sulfoxide / 12 h / 130 °C

3: sodium hydroxide / Raney Nickel / dichloromethane; ethanol

With triethylamine; sodium hydroxide; Raney Nickel; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester (203661-71-6) → tert-butyl 2-aminomethyl-6-azaspiro[3.4]octane-6-carboxylate (1239320-01-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / 1.5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 1.5 h / 20 °C

3: dimethyl sulfoxide / 12 h / 130 °C

4: sodium hydroxide / Raney Nickel / dichloromethane; ethanol

With methanol; sodium tetrahydroborate; triethylamine; sodium hydroxide; Raney Nickel; In ethanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester

tert-butyl 2-[(methylsulfonyl)oxy]-6-azaspiro[3.4]octane-6-carboxylate