methyl 4-(3,5-dihydroxyphenyl)butanoate

Base Information

Chemical Name:methyl 4-(3,5-dihydroxyphenyl)butanoate
CAS No.:71186-09-9
Molecular Formula:C₁₁H₁₄O₄
Molecular Weight:210.23
Hs Code.:

Synonyms:

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Chemical Property of methyl 4-(3,5-dihydroxyphenyl)butanoate

Chemical Property:

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Technology Process of methyl 4-(3,5-dihydroxyphenyl)butanoate

There total 9 articles about methyl 4-(3,5-dihydroxyphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28924-18-7
2-bromo-1-[3,5-bis(phenylmethoxy)phenyl]ethanone

: 71186-09-9
methyl 4-(3,5-dihydroxyphenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 2 h / Heating

2: KOH, H₂O / ethanol / 1 h / Heating

3: 0.5 h / 150 °C

4: 1.) hydrogen, glac AcOH, 2.) conc. H₂SO₄ / 1.) 20percent Pd(OH)2/C / 1.) EtOAc, RT, 1 atm, 24 h, 2.) RT, 5 h

With potassium hydroxide; sulfuric acid; water; hydrogen; sodium hydride; acetic acid; palladium dihydroxide; In tetrahydrofuran; ethanol;
DOI:10.1002/(SICI)1099-1344(199604)38:4<309::AID-JLCR775>3.0.CO;2-5

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 71186-09-9
methyl 4-(3,5-dihydroxyphenyl)butanoate

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃ / acetone / 20 h / Heating

2: 90 percent / 10percent aq. NaOH / acetone / 2 h / Heating

3: 65 percent / SOCl₂ / benzene / 5 h / Heating

4: 77 percent / (Et)3N / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, overnight

5: 96 percent / 47percent HBr / methanol; CHCl₃ / 0.17 h / -10 °C

6: NaH / tetrahydrofuran / 2 h / Heating

7: KOH, H₂O / ethanol / 1 h / Heating

8: 0.5 h / 150 °C

9: 1.) hydrogen, glac AcOH, 2.) conc. H₂SO₄ / 1.) 20percent Pd(OH)2/C / 1.) EtOAc, RT, 1 atm, 24 h, 2.) RT, 5 h

With potassium hydroxide; sodium hydroxide; thionyl chloride; sulfuric acid; water; hydrogen bromide; hydrogen; sodium hydride; potassium carbonate; acetic acid; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1002/(SICI)1099-1344(199604)38:4<309::AID-JLCR775>3.0.CO;2-5

Reference yield:

: 58605-10-0
methyl 3,5-bis(benzyloxy)benzoate

: 71186-09-9
methyl 4-(3,5-dihydroxyphenyl)butanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / 10percent aq. NaOH / acetone / 2 h / Heating

2: 65 percent / SOCl₂ / benzene / 5 h / Heating

3: 77 percent / (Et)3N / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, overnight

4: 96 percent / 47percent HBr / methanol; CHCl₃ / 0.17 h / -10 °C

5: NaH / tetrahydrofuran / 2 h / Heating

6: KOH, H₂O / ethanol / 1 h / Heating

7: 0.5 h / 150 °C

8: 1.) hydrogen, glac AcOH, 2.) conc. H₂SO₄ / 1.) 20percent Pd(OH)2/C / 1.) EtOAc, RT, 1 atm, 24 h, 2.) RT, 5 h

With potassium hydroxide; sodium hydroxide; thionyl chloride; sulfuric acid; water; hydrogen bromide; hydrogen; sodium hydride; acetic acid; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1002/(SICI)1099-1344(199604)38:4<309::AID-JLCR775>3.0.CO;2-5