(1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane

Base Information

• Chemical Name: (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane
• CAS No.: 74447-46-4
• Molecular Formula: C₁₆H₁₈O₄S
• Molecular Weight: 307.375
• Mol file: 74447-46-4.mol

Synonyms:

Chemical Property of (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane

There total 6 articles about (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H9(2)HO2 (118322-75-1) → (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane (74447-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride / methanol / 0.17 h / Ambient temperature

2: pyridine / 4 h / 0 °C

With pyridine; sodium tetrahydroborate; In methanol;

Reference yield:

2-(4-methoxyphenyl)methyl-1,3-dithiane (74447-45-3) → (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane (74447-46-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) n-butyl-lithium, 2.) deuterium oxide / 1.) hexan, tetrahydrofuran, -23 deg C, 1.5 h, 2.) 0 deg C, 14 h

2: ceric ammonium nitrate / acetonitrile / 0.05 h / Ambient temperature

3: aq. hydrochloric acid / tetrahydrofuran / 1 h / Ambient temperature

4: sodium borohydride / methanol / 0.17 h / Ambient temperature

5: pyridine / 4 h / 0 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; ammonium cerium(IV) nitrate; water-d2; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

C11H15(2)HO3 → (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane (74447-46-4)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. hydrochloric acid / tetrahydrofuran / 1 h / Ambient temperature

2: sodium borohydride / methanol / 0.17 h / Ambient temperature

3: pyridine / 4 h / 0 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; methanol;

upstream raw materials:

p-toluenesulfonyl chloride

C₉H₉⁽²⁾HO₂

2-(4-methoxyphenyl)methyl-1,3-dithiane

<2-(2)H1>-2-(4-methoxybenzyl)-1,3-dithian