74447-45-3

Upstream product

• 505-23-7 1,3 dithiane 
• 824-94-2 p-methoxybenzyl chloride 
• 109-80-8 1.3-propanedithiol 
• 5703-26-4 4-Methoxyphenylacetaldehyde 

Downstream Products

• 1268631-73-7 8-benzyl-2-(4-methoxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl 4-methylbenzenesulfonate 
• 276879-72-2 (Z)-8-benzyl-2-(4-methoxybenzylidene)-6-(4-methoxy-phenyl)imidazo[1,2-a]pyrazin-3(2H)-one 
• 1268631-74-8 2-(4-methoxybenzyl)-1,3-dithiane-2-carbaldehyde 
• 74447-44-2 1-azido-2-(4-methoxyphenyl)ethane 
• 74447-46-4 (1RS)-<1-(2)H1>-2-(4-methoxyphenyl)-1-O-tosylethane 
• 118322-75-1 C₉H₉⁽²⁾HO₂ 
• 5107-52-8 2-(p-methoxyphenyl)ethyl toluene-p-sulphonate 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 74447-60-2 <2-(2)H1>-2-(4-methoxybenzyl)-1,3-dithian 
• 42866-92-2 2-(4-methoxyphenyl)acetaldehyde dimethyl acetal 

Relevant academic research and scientific papers

Synthesis of disubstituted dithioethers: Tert -butoxide promoted elimination/ring opening of 1,3-dithianes followed by palladium-catalyzed C-S bond formation

We report the tandem base-promoted elimination/ring-opening of 2-benzyl-1,3-dithianes with subsequent cross coupling of the pendent thiol with a range of aryl bromides. A simple Pd(OAc)2/Xantphos catalyst system affects this new reaction and is

Chemical synthesis of coelenterazine and its analogs: New route by four segment-couplings

A novel and improved synthetic route includes four segment-couplings toward coelenterazine and its analogs as luminescent molecules. Regio- and chemo-selective cross coupling reactions using palladium catalysts with 5-iodo-3-bromo-2-aminopyrazine have enabled providing various aminopyrazine derivatives having different substituents. The improved synthesis of coelenterazine and its analogs employed advanced condensation with the aminopyrazines using various keto-acetal segments, which resulted in much higher yields to give the final imidazopyrazinone heterocycles than the previous method using keto-aldehydes.

Suzuki-Miyaura coupling for general synthesis of dehydrocoelenterazine applicable for 6-position analogs directing toward bioluminescence studies

Synthesis of coelenterazine analogs is in recent demand to supply more luminescent compounds with reasonable stability as substrate for the photoprotein manipulated in a living cells or particular organelle. There are limited methods for the synthesis of