ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate

Base Information

• Chemical Name: ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate
• CAS No.: 897373-24-9
• Molecular Formula: C₁₈H₂₃N₃O₂
• Molecular Weight: 313.4
• Mol file: 897373-24-9.mol

Synonyms:ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate

Chemical Property of ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate

There total 3 articles about ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + p-carboxymethylphenylhydrazine hydrochloride (57412-05-2,65476-32-6) + 3-cyclopentyl-3-oxopropanenitrile (95882-33-0) → ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate (897373-24-9)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

methyl cyclopentane carboxylate (4630-80-2) → ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate (897373-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 70 °C

2: Reflux

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

4-aminophenylacetic acid (1197-55-3) → ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate (897373-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: Reflux

With hydrogenchloride; sodium nitrite; In water;

DOI:10.1016/j.ejmech.2011.11.019

upstream raw materials:

ethanol

p-carboxymethylphenylhydrazine hydrochloride

3-cyclopentyl-3-oxopropanenitrile

methyl cyclopentane carboxylate

Downstream raw materials:

ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid