[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 906672-43-3
• Molecular Formula: C₃₁H₂₇ClN₄O₃
• Molecular Weight: 539.033
• Mol file: 906672-43-3.mol

Synonyms:

Chemical Property of [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 4 articles about [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

1-{[N-benzyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrimidoyl]-amino}-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester (628733-86-8) → 2-benzylamino-7-chloro-3-ethyl-3,4-dihydro-pyrrolo[1,2-b][1,2,5]triazepin-5-one + [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (906672-43-3)

Guidance literature:

In xylene; at 130 ℃; for 7h;

DOI:10.1016/j.bmcl.2006.05.037

Reference yield:

1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester (791780-57-9) → [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (906672-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: EDCI*HCl / CH₂Cl₂ / 20 °C

2: 25 percent / xylene / 7 h / 130 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; xylene;

DOI:10.1016/j.bmcl.2006.05.037

Reference yield:

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide (628733-85-7) → [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (906672-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: EDCI*HCl / CH₂Cl₂ / 20 °C

2: 25 percent / xylene / 7 h / 130 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; xylene;

DOI:10.1016/j.bmcl.2006.05.037

upstream raw materials:

1-{[N-benzyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrimidoyl]-amino}-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester

1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide

4-chloro-1H-pyrrole-2-carboxylic acid methyl ester

Downstream raw materials:

(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine

(+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one