4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide

Base Information

Chemical Name:4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide
CAS No.:133928-65-1
Molecular Formula:C₁₅H₁₇ClN₂OSi
Molecular Weight:304.851
Hs Code.:
DSSTox Substance ID:DTXSID401193713

Synonyms:DTXSID401193713;4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide;133928-65-1

Suppliers and Price of 4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:304.0798674
Heavy Atom Count:20
Complexity:339

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C[Si](C)(C)C1=C(C=CN=C1C(=O)NC2=CC=CC=C2)Cl

Technology Process of 4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide

There total 4 articles about 4-Chloro-N-phenyl-3-(trimethylsilyl)-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53750-66-6
4-chloro-pyridine-2-carbonyl chloride

: 133928-65-1
4-chloro-3-trimethylsilylpicolinanilide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃

2: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h 2.) -78 deg C, 1 h -> r. t., 1 h

With n-butyllithium; triethylamine; In chloroform;
DOI:10.1016/S0040-4020(01)96912-1

Reference yield:

: 35895-54-6
2-carboxy-4-chloropyridine-1-oxide

: 133928-65-1
4-chloro-3-trimethylsilylpicolinanilide

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₃ / CHCl₃ / 0.5 h / Heating

2: Et₃N / CHCl₃

3: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h 2.) -78 deg C, 1 h -> r. t., 1 h

With n-butyllithium; triethylamine; phosphorus trichloride; In chloroform;
DOI:10.1016/S0040-4020(01)96912-1

Reference yield:

: 14933-78-9
2-carboxy-4-nitropyridine-1-oxide

: 133928-65-1
4-chloro-3-trimethylsilylpicolinanilide

Guidance literature:: Multi-step reaction with 4 steps

1: 69.4 percent / HCl(gas) / methanol / 5 h / Heating

2: PCl₃ / CHCl₃ / 0.5 h / Heating

3: Et₃N / CHCl₃

4: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h 2.) -78 deg C, 1 h -> r. t., 1 h

With hydrogenchloride; n-butyllithium; triethylamine; phosphorus trichloride; In methanol; chloroform;
DOI:10.1016/S0040-4020(01)96912-1