14933-78-9

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Nitropyridine-2-carboxylic acid 1-oxide is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its presence in the molecular structure allows for the development of new medications with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical sector, 4-Nitropyridine-2-carboxylic acid 1-oxide is utilized as a key intermediate in the production of different agrochemicals, contributing to the development of effective solutions for agricultural applications.
Used in Organic Synthesis:
4-Nitropyridine-2-carboxylic acid 1-oxide is employed as a valuable precursor in organic synthesis, where its nitro group is instrumental in the preparation of other nitrogen-containing organic compounds, expanding the range of possible chemical reactions and products.
Used in Materials Science:
Due to its unique chemical properties, 4-Nitropyridine-2-carboxylic acid 1-oxide has potential applications in materials science, where it can be used to develop new materials with specific properties for various industrial uses.
Overall, 4-Nitropyridine-2-carboxylic acid 1-oxide is a significant compound in the field of chemistry, with a wide range of applications across different industries, underpinning its importance in both research and commercial applications.

InChI:InChI=1/C6H4N2O5/c9-6(10)5-3-4(8(12)13)1-2-7(5)11/h1-3,5H/p+1

Upstream product

• 824-40-8 2-pyridinecarboxylic acid N-oxide 
• 98-98-6 2-Picolinic acid 
• 13509-19-8 4-nitropyridine-2-carboxylic acid 

Downstream Products

• 57948-55-7 4-Nitro-1-oxy-pyridine-2-carbonyl chloride 
• 126798-20-7 4-methoxypicolinanilide 
• 126798-23-0 3-methyl-4-methoxypicolinanilide 
• 126798-29-6 1,3-dimethyl-4-pyridone-2-carboxanilide 
• 126798-22-9 4-nitropicolinanilide 
• 126798-30-9 1-(p-methoxyphenyl)-furo<3,4-b>pyridine-3,7(1H,4H)-dione 
• 126798-25-2 7-methoxy-1-(p-methoxyphenyl)-furo<3,4-b>pyridine-3(1H)-one 
• 100047-36-7 4-aminopyridine-2-carboxylic acid 
• 133929-13-2 7-chloro-1-(p-methoxyphenyl)-furo<3,4-b>pyridine-3(1H)-one 
• 133928-70-8 7-chloro-1-hydroxy-2-phenyl-pyrrolo<3,4-b>pyridine-3(1H)-one 
• 133928-65-1 4-chloro-3-trimethylsilylpicolinanilide 
• 133928-66-2 C₁₂H₈⁽²⁾HClN₂O 
• 133928-61-7 N-phenyl-4-chloro-2-pyridinecarboxamide 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 

Relevant academic research and scientific papers

1H and 17O NMR study of H-bond dynamics in picolinic acid N-oxide solutions in acetonitrile-h3 and acetonitrile?d3: Novel aspects of old casus

Despite apparent similarity, two isotopomers of acetonitrile (ACN-h3 and ACN-d3) show unexpected differences in their structural and dynamic properties. These differences cannot be fully understood within the usual isotope effect and therefore called as unresolved casus. Sensing the solvent properties, the H-bond dynamics of picolinic acid N-oxide (PANO) in ACN was studied using 1H and 17O NMR. Several overlapping factors, like the presence of micro-traces of water, liquid-liquid equilibrium, effect of ionic ingredient, etc., which may cause the observed anomalies in the dependences of PANO chemical shift and signal width on temperature, were analyzed. The deuterium isotope effect on the phase separation in organic solute/water mixtures was deduced to be the crucial factor inducing those surprising differences between ACN-h3 and ACN-d3. Thus the casus could be resolved within the second-order phase transition model, in which the vibrational contributions to the intermolecular interaction energies would be properly taken into account.

Structural designs and property characterizations for second-harmonic generation materials

Second-harmonic generation (SHG) materials only exist in solids that have no inversion center space groups, and they are constructed by the building blocks or chromophores of noncentrosymmetricity (NCS). In this chapter, we employed one or multiple chromophores that result from the coordination structure distortions of a d0 cation, polar displacement of d 10 cation center, a stereochemically active lone pair (SCALP) of cations, and asymmetrical delocalization π-charge systems, as building blocks to obtain some new compounds with NCS space group. The single-crystal structures were characterized, and physical properties, in particular SHG responses, were measured for these compounds. The electronic structures and density of states were calculated by DFT method, and the SHG properties are simulated to gain an insight into the relations between structure and NLO properties for the materials. The electronic origination of large SHG responses was assigned in terms of the calculated results.

APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS. PART 7. SYNTHESIS AND METALLATION OF 4-METHOXYPICOLIN- AND 2-METHOXYISONICOTIN-ANILIDES. A USEFUL METHOD FOR PREPARATION OF 2,3,4-TRISUBSTITUTED PYRIDINES

The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines, is described.The resulted C-alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.