14933-78-9

Basic information

• Product Name: 4-Nitropyridine-2-carboxylic acid 1-oxide
• Synonyms: 4-nitropyridine-2-carboxylic acid 1-oxide;4-Nitro-2-pyridinecarboxylic acid 1-oxide;2-Pyridinecarboxylic acid, 4-nitro-, 1-oxide;4-NNITROPYRIDINE-2-CARBOXYLIC ACID 1-OXIDE;2-Carboxy-4-nitropyridine 1-oxide;4-Nitropicolinic acid 1-oxide;4-nitro-1-oxidopyridin-1-ium-2-carboxylic acid;4-nitro-2-Pyridine carbocylic acid 1-oxide
• CAS NO: 14933-78-9
• Molecular Formula: C₆H₄N₂O₅
• Molecular Weight: 184.11
• EINECS: 239-008-6
• Product Categories: Pyridines
• Mol File: 14933-78-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 148 °C
• Boiling Point: 553.6 °C at 760 mmHg
• Flash Point: 288.6 °C
• Appearance: /
• Density: 1.69g/cm³
• PKA: 1.00±0.50(Predicted)
• CAS DataBase Reference: 4-Nitropyridine-2-carboxylic acid 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitropyridine-2-carboxylic acid 1-oxide(14933-78-9)
• EPA Substance Registry System: 4-Nitropyridine-2-carboxylic acid 1-oxide(14933-78-9)

Safety Data

• Hazardous Substances Data: 14933-78-9(Hazardous Substances Data)

Usage

General Description

4-Nitropyridine-2-carboxylic acid 1-oxide is a chemical compound with the molecular formula C6H4N2O5. It is a yellow solid with a nitro group and a carboxylic acid group in its structure. 4-Nitropyridine-2-carboxylic acid 1-oxide is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its nitro group makes it a valuable precursor for the preparation of other nitrogen-containing organic compounds. Additionally, it has potential applications in the field of organic synthesis and materials science due to its unique chemical properties. Overall, 4-Nitropyridine-2-carboxylic acid 1-oxide has several important industrial and research applications, making it an important compound in the field of chemistry.

InChI:InChI=1/C6H4N2O5/c9-6(10)5-3-4(8(12)13)1-2-7(5)11/h1-3,5H/p+1

Upstream product

• 98-98-6 2-Picolinic acid 
• 824-40-8 2-pyridinecarboxylic acid N-oxide 
• 13509-19-8 4-nitropyridine-2-carboxylic acid 

Downstream Products

• 100047-36-7 4-aminopyridine-2-carboxylic acid 
• 133929-13-2 7-chloro-1-(p-methoxyphenyl)-furo<3,4-b>pyridine-3(1H)-one 
• 133928-70-8 7-chloro-1-hydroxy-2-phenyl-pyrrolo<3,4-b>pyridine-3(1H)-one 
• 133928-65-1 4-chloro-3-trimethylsilylpicolinanilide 
• 133928-66-2 C₁₂H₈⁽²⁾HClN₂O 
• 133928-61-7 N-phenyl-4-chloro-2-pyridinecarboxamide 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 126798-25-2 7-methoxy-1-(p-methoxyphenyl)-furo<3,4-b>pyridine-3(1H)-one 
• 126798-30-9 1-(p-methoxyphenyl)-furo<3,4-b>pyridine-3,7(1H,4H)-dione 
• 126798-22-9 4-nitropicolinanilide 
• 126798-29-6 1,3-dimethyl-4-pyridone-2-carboxanilide 
• 126798-23-0 3-methyl-4-methoxypicolinanilide 
• 126798-20-7 4-methoxypicolinanilide 
• 57948-55-7 4-Nitro-1-oxy-pyridine-2-carbonyl chloride 

Relevant articles and documents

1H and 17O NMR study of H-bond dynamics in picolinic acid N-oxide solutions in acetonitrile-h3 and acetonitrile?d3: Novel aspects of old casus

Despite apparent similarity, two isotopomers of acetonitrile (ACN-h3 and ACN-d3) show unexpected differences in their structural and dynamic properties. These differences cannot be fully understood within the usual isotope effect and therefore called as unresolved casus. Sensing the solvent properties, the H-bond dynamics of picolinic acid N-oxide (PANO) in ACN was studied using 1H and 17O NMR. Several overlapping factors, like the presence of micro-traces of water, liquid-liquid equilibrium, effect of ionic ingredient, etc., which may cause the observed anomalies in the dependences of PANO chemical shift and signal width on temperature, were analyzed. The deuterium isotope effect on the phase separation in organic solute/water mixtures was deduced to be the crucial factor inducing those surprising differences between ACN-h3 and ACN-d3. Thus the casus could be resolved within the second-order phase transition model, in which the vibrational contributions to the intermolecular interaction energies would be properly taken into account.

APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS. PART 7. SYNTHESIS AND METALLATION OF 4-METHOXYPICOLIN- AND 2-METHOXYISONICOTIN-ANILIDES. A USEFUL METHOD FOR PREPARATION OF 2,3,4-TRISUBSTITUTED PYRIDINES

The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines, is described.The resulted C-alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.