(E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester

Base Information

• Chemical Name: (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester
• CAS No.: 86530-09-8
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 86530-09-8.mol

Synonyms:

Chemical Property of (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester

There total 3 articles about (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(3-Methoxy-4-methoxycarbonyloxy-phenyl)-acrylic acid piperidin-1-yl ester (86530-08-7) → (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester (86530-09-8)

Guidance literature:

With ammonium hydroxide; In methanol; for 3h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(00)81595-6

Reference yield:

N-hydroxypiperidine (4801-58-5) → (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester (86530-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N(C₂H₅)3 / 1) CH₂Cl₂, O deg C_., 1 h., 2) room temp., 18 h

2: NH₄OH / methanol / 3 h / Ambient temperature

With ammonium hydroxide; triethylamine; In methanol;

DOI:10.1016/S0040-4039(00)81595-6

Reference yield:

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) → (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester (86530-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N(C₂H₅)3 / 1) CH₂Cl₂, O deg C_., 1 h., 2) room temp., 18 h

2: NH₄OH / methanol / 3 h / Ambient temperature

With ammonium hydroxide; triethylamine; In methanol;

DOI:10.1016/S0040-4039(00)81595-6

upstream raw materials:

(E)-3-(3-Methoxy-4-methoxycarbonyloxy-phenyl)-acrylic acid piperidin-1-yl ester

N-hydroxypiperidine

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Downstream raw materials:

(E)-N-(2-(1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

di-(E)-feruloylspermidine

(2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide)