(4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

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Chemical Name:(4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide
CAS No.:1350519-94-6
Molecular Formula:C₃₂H₄₂N₈O₆
Molecular Weight:634.735
Hs Code.:

(4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

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Chemical Property of (4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

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Technology Process of (4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

There total 15 articles about (4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350519-99-1
C₂₆H₃₅N₃O₄

: 1350519-94-6
(4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.05 h / 20 °C / Inert atmosphere

4.2: 24 h / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C / Inert atmosphere

5.2: 0.05 h / Inert atmosphere

5.3: 18 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.079

Reference yield:

: 1350520-01-2
C₃₄H₄₅N₅O₇

: 1350519-94-6
(4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.05 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C / Inert atmosphere

3.2: 0.05 h / Inert atmosphere

3.3: 18 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.079

Reference yield:

: 1350520-00-1
(S)-2-amino-N-(1-(benzylamino)-1-oxo-3-phenylpropan-2-yl)-3-methylbutanamide hydrochloride

: 1350519-94-6
(4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.05 h / 20 °C / Inert atmosphere

3.2: 24 h / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C / Inert atmosphere

4.2: 0.05 h / Inert atmosphere

4.3: 18 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.079