bi(7-deoxydaunomycinon-7-yl) bis-quinone

Base Information

• Chemical Name: bi(7-deoxydaunomycinon-7-yl) bis-quinone
• CAS No.: 131079-86-2
• Molecular Formula: C₄₂H₃₄O₁₄
• Molecular Weight: 762.724
• Mol file: 131079-86-2.mol

Synonyms:

Chemical Property of bi(7-deoxydaunomycinon-7-yl) bis-quinone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of bi(7-deoxydaunomycinon-7-yl) bis-quinone

There total 3 articles about bi(7-deoxydaunomycinon-7-yl) bis-quinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

DNR (20830-81-3) → bi(7-deoxydaunomycinon-7-yl) bis-quinone (131079-86-2) + 7-deoxydaunomycin (32384-98-8,35994-56-0)

Guidance literature:

With sodium dithionite; In water; dimethyl sulfoxide; at 20 ℃; for 72h; Product distribution; other reducing agents, other time;

DOI:10.1021/ja00034a054

Reference yield: 20.0%

7-deoxydaunomycinnone quinone methide (85337-17-3) → (+)-Daunomycinone (21794-55-8) + bi(7-deoxydaunomycinon-7-yl) bis-quinone (131079-86-2) + 7-deoxydaunomycin (32384-98-8,35994-56-0) + 7-deoxy-7,13-epidioxydaunomycinol (131436-58-3)

Guidance literature:

With oxygen; In water; at 0 ℃; Further byproducts given; pH 8.2;

Reference yield: 20.0%

7-deoxydaunomycinnone quinone methide (85337-17-3) → (+)-Daunomycinone (21794-55-8) + 9-acetyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-4-methoxy-7-oxonaphthacene-5,12-quinone (32469-41-3) + 7-epidaunomycinone (59325-98-3) + bi(7-deoxydaunomycinon-7-yl) bis-quinone (131079-86-2) + 7-deoxydaunomycin (32384-98-8,35994-56-0) + 7-deoxy-7,13-epidioxydaunomycinol (131436-58-3)

Guidance literature:

With oxygen; In water; at 0 ℃; Mechanism;

upstream raw materials:

DNR

7-deoxydaunomycinnone quinone methide

Refernces

• 1、 Gaudiano, Giorgio,Koch, Tad H.. "Reaction of the quinone methide from reductive glycosidic cleavage of daunomycin with molecular oxygen. Evidence for semiquinone methide formation". . p. 9423 - 9425. Retrieved 2007/10/02.