2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide

Base Information

• Chemical Name: 2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide
• CAS No.: 870615-97-7
• Molecular Formula: C₂₃H₂₆Cl₃N₃O₄
• Molecular Weight: 514.836
• Mol file: 870615-97-7.mol

Synonyms:

Chemical Property of 2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide

There total 1 articles about 2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

n-hexyl isocyanide (15586-23-9) + 4-chlorobenzylamine (104-86-9) + chloroacetic acid (79-11-8) + 2-chloro-5-nitrobenzaldehyde (6361-21-3) → 2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide (870615-97-7)

Guidance literature:

In methanol; at 20 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2005.09.071

Reference yield:

2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide (870615-97-7) → 4-(4-chloro)benzyl-7-nitro-3-oxo-2,3,4,5-tetrahydrobenzo[1,4]thiazepin-5-carboxylic acid N-hexyl amide

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 12 h / 20 °C

2: aq. KOH / ethanol / 2 h / Heating

With potassium hydroxide; In ethanol; acetone;

DOI:10.1016/j.tetlet.2005.09.071

Reference yield:

2-[N-chloroacetyl-N-(4-chloro)benzyl]amino-2-(2-chloro-5-nitro)phenylacetic acid N-hexyl amide (870615-97-7) + thiourea (17356-08-0) → 2-[carbamimidoylsulfanylacetyl-(4-chloro-benzyl)-amino]-2-(2-chloro-5-nitro-phenyl)-N-hexyl-acetamide; hydrochloride

Guidance literature:

In acetone; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2005.09.071

upstream raw materials:

n-hexyl isocyanide

4-chlorobenzylamine

chloroacetic acid

2-chloro-5-nitrobenzaldehyde