2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester
• CAS No.: 135716-20-0
• Molecular Formula: C₄₃H₆₈O₅Si
• Molecular Weight: 693.095

Synonyms:

Chemical Property of 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester

There total 6 articles about 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1S,2S,3S,6S)-6-Allyl-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-cyclohexyl]-methanol (135716-19-7) → 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester (135716-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd-C / methanol

2: DMAP / pyridine

With dmap; hydrogen; palladium on activated charcoal; In pyridine; methanol;

DOI:10.1016/0040-4039(91)80587-V

Reference yield:

(4aS,7S,8S,8aS)-8-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-7-methyl-octahydro-isochromen-3-ol (136491-76-4) → 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester (135716-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: KHMDS / toluene

2: H₂ / 10percent Pd-C / methanol

3: DMAP / pyridine

With dmap; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In pyridine; methanol; toluene;

DOI:10.1016/0040-4039(91)80587-V

Reference yield:

(4aS,7S,8S,8aS)-8-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-7-methyl-octahydro-isochromen-3-one (135734-44-0) → 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl ester (135716-20-0)

Guidance literature:

Multi-step reaction with 4 steps

1: DiBAL / toluene / -78 °C

2: KHMDS / toluene

3: H₂ / 10percent Pd-C / methanol

4: DMAP / pyridine

With dmap; hydrogen; potassium hexamethylsilazane; diisobutylaluminium hydride; palladium on activated charcoal; In pyridine; methanol; toluene;

DOI:10.1016/0040-4039(91)80587-V

upstream raw materials:

2,2-dimethylbutanoyl chloride

[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexyl]-methanol

[(1S,2S,3S,6S)-6-Allyl-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-cyclohexyl]-methanol

(4aS,7S,8S,8aS)-8-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-7-methyl-octahydro-isochromen-3-ol

Downstream raw materials:

2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-carboxymethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[(2,2-Dimethyl-1-oxobutoxy) methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

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