POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE

Base Information

• Chemical Name: POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE
• CAS No.: 67881-99-6
• Molecular Formula: C₁₁H₂₂NO₆P
• Molecular Weight: 295.273
• Mol file: 67881-99-6.mol

Synonyms:2-(Methacryloyloxy)ethylphosphorylcholine homopolymer;2-(Methacryloyloxy)ethyl-2'-(trimethylammonio)ethyl phosphate homopolymer;2-Methacryloyloxyethylphosphorylcholine polymer;2-[Hydroxy[2-[(2-methyl-1-oxo-2-propenyl)oxy]ethoxy]phosphinyl]-N,N,N-trimethylethanaminiuminner salt homopolymer; HM 500; Lipidure HM; Lipidure HM 500; Lipidure HM 600;Poly(2-methacryloyloxyethylphosphocholine);Poly(2-methacryloyloxyethylphosphorylcholine); Vital Polymer

Chemical Property of POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE

There total 9 articles about POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C11H23Br2NO6P(1+)*Cl(1-) → 2-methacryloyloxyethyl phosphorylcholine (67881-98-5,67881-99-6)

Guidance literature:

With zinc; In ethanol; at 0 ℃;

Reference yield: 37.0%

Ethylene 2-(methacryloyloxy)ethyl phosphate (82793-19-9) + trimethylamine (75-50-3) → 2-methacryloyloxyethyl phosphorylcholine (67881-98-5,67881-99-6)

Guidance literature:

In acetonitrile; at 50 ℃; for 48h;

DOI:10.1039/a910270l

Reference yield:

2-methyl-2-propenoic acid 2-hydroxyethyl ester (868-77-9,141668-69-1,25736-86-1,82601-55-6,25249-16-5) → 2-methacryloyloxyethyl phosphorylcholine (67881-98-5,67881-99-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-diisopropylamine tetrazolide / dichloromethane / 0.33 h

2: 4,5-dichloroimidazole / acetonitrile / 16 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

4: acetonitrile / 24 h / 75 °C

With N,N-diisopropylamine tetrazolide; 4,5-dichloroimidazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; 1: Substitution / 2: Substitution / 3: Oxidation / 4: Amination;

DOI:10.1039/a910270l

upstream raw materials:

Ethylene 2-(methacryloyloxy)ethyl phosphate

trimethylamine

2-Bromoethyl 2-cyanoethyl-2-(methacryloyloxy)ethyl phosphate

2-methyl-2-propenoic acid 2-hydroxyethyl ester

Refernces

• 1、 -. "Application of nanoparticle containing orlistat in preparing anti-hepatitis B virus medicine". Paragraph 0084; 0085; 0088. . Retrieved 2018/10/11.
• 2、 -. "Composition containing orlistat and GLP-1 receptor agonist, and use thereof". Paragraph 0121; 0122; 0125. . Retrieved 2019/01/08.