C₄₂H₄₅N₅O₉S

Base Information

• Chemical Name: C₄₂H₄₅N₅O₉S
• CAS No.: 1434081-73-8
• Molecular Formula: C₄₂H₄₅N₅O₉S
• Molecular Weight: 795.913
• Mol file: 1434081-73-8.mol

Synonyms:

Chemical Property of C₄₂H₄₅N₅O₉S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₄₅N₅O₉S

There total 7 articles about C₄₂H₄₅N₅O₉S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H45N3O8Si (1434081-80-7) → C42H45N5O9S (1434081-73-8)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2: 2,6-dimethylpyridine / dichloromethane / 20 h / 20 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 3.5 h / 35 °C

4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.25 h / 0 - 20 °C

5: toluene / 20 °C

With 2,6-dimethylpyridine; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;

DOI:10.1021/jm400397x

Reference yield:

tert-butyl ((((2R,3R)-5-(S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate (1314311-47-1) → C42H45N5O9S (1434081-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride hydrate / ethanol / 70 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With tin(II) chloride hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

DOI:10.1021/jm400241j

Reference yield:

N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide (1434081-78-3) → C42H45N5O9S (1434081-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 3.5 h / 35 °C

2: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.25 h / 0 - 20 °C

3: toluene / 20 °C

With palladium 10% on activated carbon; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In ethanol; dichloromethane; toluene;

DOI:10.1021/jm400397x

upstream raw materials:

tert-butyl ((((2R,3R)-5-(S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

C₃₁H₄₅N₃O₈Si

C₂₄H₃₁N₃O₆

N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

Refernces

• 1、 Scully, Stephen S.,Tang, Alicia J.,Lundh, Morten,Mosher, Carrie M.,Perkins, Kedar M.,Wagner, Bridget K.. "Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility". . p. 4125 - 4129. Retrieved 2013/06/27.