2-METHYL-2-PHENYL-CYCLOHEXANONE

Base Information

• Chemical Name: 2-METHYL-2-PHENYL-CYCLOHEXANONE
• CAS No.: 17206-54-1
• Molecular Formula: C13H16 O
• Molecular Weight: 188.269
• Hs Code.: 2914399090
• Mol file: 17206-54-1.mol

Synonyms:2-Methyl-2-phenylcyclohexanone;NSC 409889

Chemical Property of 2-METHYL-2-PHENYL-CYCLOHEXANONE

Chemical Property:

• Vapor Pressure: 0.00151mmHg at 25°C
• Boiling Point: 295.6°Cat760mmHg
• Flash Point: 123.2°C
• PSA: 17.07000
• Density: 1.014g/cm³
• LogP: 3.08740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-methyl-2-phenylcyclohexanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-2-PHENYL-CYCLOHEXANONE

There total 13 articles about 2-METHYL-2-PHENYL-CYCLOHEXANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-trimethylsilyloxy-2-methyl-1-cyclohexene (19980-35-9) → 2-methyl-2-phenyl-cyclohexanone (17206-54-1)

Guidance literature:

In tetrahydrofuran; at -40 - 20 ℃; for 2.5h;

DOI:10.1021/ja030150k

Reference yield: 88.0%

(RS)-2-phenylcyclohexanone (1444-65-1) + methyl iodide (74-88-4) → 2-methyl-2-phenyl-cyclohexanone (17206-54-1)

Guidance literature:

(RS)-2-phenylcyclohexanone; With potassium tert-butylate; In tert-butyl alcohol; for 0.75h;

methyl iodide; In tert-butyl alcohol; at 20 ℃; for 2.5h;

DOI:10.1021/acs.joc.7b00802

Reference yield: 82.0%

1-hydroxy-α-methyl-α-phenyl-cyclopentanemethanol (4235-11-4) → 2-methyl-2-phenyl-cyclohexanone (17206-54-1)

Guidance literature:

With sulfuric acid; at -5 - 0 ℃;

DOI:10.1016/j.tetlet.2004.03.109

upstream raw materials:

(RS)-2-phenylcyclohexanone

methyl iodide

2-chloro-2-methylcyclohexanone

lithium diphenylcuprate

Downstream raw materials:

1-methylcyclohexylbenzene

2,3-Dimethyl-3-phenyl-cyclohex-1-en

2-Methyl-2-phenylcyclohexanol

(R)-(+)-2-methyl-2-phenylcyclohexanone