ethyl 6--hexanoate

Base Information

• Chemical Name: ethyl 6--hexanoate
• CAS No.: 136413-21-3
• Molecular Formula: C₂₃H₃₆N₂O₆
• Molecular Weight: 436.549
• Mol file: 136413-21-3.mol

Synonyms:

Chemical Property of ethyl 6--hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6--hexanoate

There total 3 articles about ethyl 6--hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

6-bromo-hexanoic acid ethyl ester (25542-62-5) + benzyl 3-(t-butoxycarbonylamino)propanohydroxamate (136413-17-7) → 6-(N-Benzyloxy-3-tert-butoxycarbonylamino-propionimidoyloxy)-hexanoic acid ethyl ester (136413-24-6) + ethyl 6--hexanoate (136413-21-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

N-benzyloxyamine (622-33-3) → ethyl 6--hexanoate (136413-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Et₃N, isobutyl chloroformate / tetrahydrofuran / 1.) -15 deg C, 3 h, 2.) r.t., 20 h

2: 30 percent / 60percent NaH / dimethylformamide / 100 °C

With sodium hydride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) → ethyl 6--hexanoate (136413-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Et₃N, isobutyl chloroformate / tetrahydrofuran / 1.) -15 deg C, 3 h, 2.) r.t., 20 h

2: 30 percent / 60percent NaH / dimethylformamide / 100 °C

With sodium hydride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

6-bromo-hexanoic acid ethyl ester

benzyl 3-(t-butoxycarbonylamino)propanohydroxamate

N-benzyloxyamine

3-(tert-butyloxycarbonylamino)propionic acid

Downstream raw materials:

tris-(2-<6--hexanamido>ethyl)amine

6-[Benzyloxy-(3-tert-butoxycarbonylamino-propionyl)-amino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester