4-carboxybenzhydrol

Base Information

• Chemical Name: 4-carboxybenzhydrol
• CAS No.: 540727-45-5
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.247
• Mol file: 540727-45-5.mol

Synonyms:

Chemical Property of 4-carboxybenzhydrol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-carboxybenzhydrol

There total 15 articles about 4-carboxybenzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-iodobenzoic acid (619-58-9) + benzaldehyde (100-52-7) → 4-carboxybenzhydrol (540727-45-5,540727-46-6,579-52-2)

Guidance literature:

4-iodobenzoic acid; With methylmagnesium chloride; lithium chloride; In tetrahydrofuran; at -20 ℃; for 0.333333h;

With TurboGrignard; In tetrahydrofuran; at -20 - 20 ℃; for 0.75h;

benzaldehyde; In tetrahydrofuran; at -20 - 20 ℃; Further stages.;

DOI:10.1039/b618923g

Reference yield: 90.0%

→ 4-carboxybenzhydrol (540727-45-5,540727-46-6,579-52-2)

Guidance literature:

Reference yield: 87.0%

4-carboxybenzophenone (611-95-0) → 4-carboxybenzhydrol (540727-45-5,540727-46-6,579-52-2)

Guidance literature:

4-carboxybenzophenone; With 1,2-disodiotetraphenylethane; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With water; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1021/jo901183x

upstream raw materials:

4-carboxybenzophenone

methyl 4-Benzoylbenzoate

benzophenone-4-carboxylic acid radical anion

4-carboxybenzophenone ketyl

Downstream raw materials:

methyl 4-(hydroxyphenylmethyl)benzoate

4-Benzoylbenzoesaeure-pinacol

4-(phenyl-piperazin-1-yl-methyl)-benzoic acid tert-butyl ester