4-(HYDROXY-PHENYL-METHYL)-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-(HYDROXY-PHENYL-METHYL)-BENZOIC ACID METHYL ESTER
• CAS No.: 108419-03-0
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.274
• Hs Code.: 2918199090
• Mol file: 108419-03-0.mol

Synonyms:p-Toluicacid, a-hydroxy-a-phenyl-, methyl ester (6CI);4-(Methoxycarbonyl)diphenylmethanol; 4-Methoxycarbonylphenyl(phenyl)methanol;Methyl 4-(hydroxyphenylmethyl)benzoate; Methyl a-hydroxy-a-phenyl-p-toluate; a-Phenyl-4-(methoxycarbonyl)benzenemethanol

Chemical Property of 4-(HYDROXY-PHENYL-METHYL)-BENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 397.781°C at 760 mmHg
• Flash Point: 168.748°C
• PSA: 46.53000
• Density: 1.182g/cm³
• LogP: 2.55490

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(HYDROXY-PHENYL-METHYL)-BENZOIC ACID METHYL ESTER

There total 24 articles about 4-(HYDROXY-PHENYL-METHYL)-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-formylbenzoate (1571-08-0) + phenylboronic acid (98-80-6) → methyl 4-(hydroxyphenylmethyl)benzoate (108419-03-0,108475-89-4)

Guidance literature:

With tri-tert-butyl phosphine; {rhodium(acetylacetonate)(cis-cyclooctene)2}; In 1,2-dimethoxyethane; water; at 25 - 28 ℃; for 16h;

DOI:10.1021/jo000187c

Reference yield: 99.0%

phenylmagnesium bromide (100-58-3) + methyl 4-formylbenzoate (1571-08-0) → methyl 4-(hydroxyphenylmethyl)benzoate (108419-03-0,108475-89-4)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 0.166667h; Flow reactor;

DOI:10.1021/acs.oprd.9b00515

Reference yield: 96.0%

trimethyl(phenyl)stannane (934-56-5) + methyl 4-formylbenzoate (1571-08-0) → methyl 4-(hydroxyphenylmethyl)benzoate (108419-03-0,108475-89-4)

Guidance literature:

BF4; In tetrahydrofuran; at 60 ℃; for 5h;

DOI:10.1039/a704108j

upstream raw materials:

diazomethane

4-carboxybenzhydrol

methyl 4-iodobenzoate

benzaldehyde

Downstream raw materials:

4-carboxybenzophenone

methyl 4-Benzoylbenzoate

methyl α-(2-dimethylaminoethoxy)-α-phenyl-p-toluate

Refernces

• 1、 Lineros-Rosa, Mauricio,Miranda, Miguel A.,Lhiaubet-Vallet, Virginie. "A Sunscreen-Based Photocage for Carbonyl Groups". . p. 7205 - 7211. Retrieved 2020.
• 2、 Durandetti,Nedelec,Perichon. "An electrochemical coupling of organic halide with aldehydes, catalytic in chromium and nickel salts. the Nozaki-Hiyama-Kishi reaction.". . p. 2073 - 2076. Retrieved 2001.
• 3、 Oi, Shuichi,Moro, Mitsutoshi,Inoue, Yoshio. "Rhodium-catalysed arylation of aldehydes with arylstannanes". . p. 1621 - 1622. Retrieved 1997.
• 4、 Kondo, Yoshinori,Fujinami, Michihiko,Uchiyama, Masanobu,Sakamoto, Takao. "Lithium tri-tert-butylzincate as a chemoselective metallating reagent for functionalized organic halides". . p. 799 - 800. Retrieved 1997.
• 5、 Zhang, Xiao,Yang, Chao,Gao, Han,Wang, Lei,Guo, Lin,Xia, Wujiong. "Reductive arylation of aliphatic and aromatic aldehydes with cyanoarenes by electrolysis for the synthesis of alcohols". supporting information. p. 3472 - 3476. Retrieved 2021/05/10.
• 6、 -. "INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR". Page/Page column 119. . Retrieved 2021/10/11.