ETHYL 2-(4-CHLOROPHENYL)-1-INDOLIZINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-(4-CHLOROPHENYL)-1-INDOLIZINECARBOXYLATE
• CAS No.: 477862-74-1
• Molecular Formula: C₁₇H₁₄ClNO₂
• Molecular Weight: 299.757
• Mol file: 477862-74-1.mol

Synonyms:

Chemical Property of ETHYL 2-(4-CHLOROPHENYL)-1-INDOLIZINECARBOXYLATE

Chemical Property:

Purity/Quality:

Ethyl 2-(4-chlorophenyl)-1-indolizinecarboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of ETHYL 2-(4-CHLOROPHENYL)-1-INDOLIZINECARBOXYLATE

There total 5 articles about ETHYL 2-(4-CHLOROPHENYL)-1-INDOLIZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Ethyl isocyanoacetate (2999-46-4) + 1-(2-(4-chlorophenyl)-2-oxoethyl)pyridinium bromide (26031-66-3) → ethyl 2-(4-chlorophenyl)indolizine-1-carboxylate (477862-74-1)

Guidance literature:

With triethylamine; silver carbonate; In 1,4-dioxane; at 25 ℃; for 10h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02754

Reference yield: 70.0%

ethyl 2-(pyridinyl-2)acetate (2739-98-2) + 2-iodo-4'-chloroacetophenone (53896-48-3) → ethyl 2-(4-chlorophenyl)indolizine-1-carboxylate (477862-74-1)

Guidance literature:

at 80 ℃; Mechanism;

DOI:10.1021/acs.joc.5b00477

Reference yield: 68.0%

ethyl 2-(pyridinyl-2)acetate (2739-98-2) + para-chloroacetophenone (99-91-2) → ethyl 2-(4-chlorophenyl)indolizine-1-carboxylate (477862-74-1)

Guidance literature:

With di-tert-butyl peroxide; iodine; copper(ll) bromide; at 80 ℃; for 5h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Inert atmosphere;

DOI:10.1021/acs.joc.5b00477

upstream raw materials:

ethyl 2-(pyridinyl-2)acetate

2-iodo-4'-chloroacetophenone

para-chloroacetophenone

Ethyl isocyanoacetate

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