(R)-ethyl 2-chloro-4-phenylbutyrate

Base Information

• Chemical Name: (R)-ethyl 2-chloro-4-phenylbutyrate
• CAS No.: 121819-67-8
• Molecular Formula: C₁₂H₁₅ClO₂
• Molecular Weight: 226.703
• Mol file: 121819-67-8.mol

Synonyms:

Chemical Property of (R)-ethyl 2-chloro-4-phenylbutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 2-chloro-4-phenylbutyrate

There total 4 articles about (R)-ethyl 2-chloro-4-phenylbutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethanol (64-17-5) + (R)-2-chloro-4-phenylbutanoic acid (121819-66-7) → (R)-ethyl 2-chloro-4-phenylbutyrate (121819-67-8)

Guidance literature:

With thionyl chloride; for 24h; Ambient temperature;

DOI:10.1248/cpb.37.280

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → (R)-ethyl 2-chloro-4-phenylbutyrate (121819-67-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 45 percent / methanol; H₂O / 8 h / 70 °C

2: 99.3 percent / NH₄Cl / aq. NH₃ / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9

3: 1.) NaNO₂, 2N H₂SO₄; 2.) KCl, NaNO₂, 3N H₂SO₄ / 1.) 50percent CH₃COOH, r.t., 24 h; 2.) 50percent CH₃COOH, 0-5 deg C, 1 h

4: 94 percent / SOCl₂ / 24 h / Ambient temperature

With thionyl chloride; sulfuric acid; potassium chloride; ammonium chloride; sodium nitrite; In methanol; ammonium hydroxide; water;

DOI:10.1248/cpb.37.280

Reference yield:

5-phenylethyl-imidazolidine-2,4-dione (120379-81-9) → (R)-ethyl 2-chloro-4-phenylbutyrate (121819-67-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 99.3 percent / NH₄Cl / aq. NH₃ / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9

2: 1.) NaNO₂, 2N H₂SO₄; 2.) KCl, NaNO₂, 3N H₂SO₄ / 1.) 50percent CH₃COOH, r.t., 24 h; 2.) 50percent CH₃COOH, 0-5 deg C, 1 h

3: 94 percent / SOCl₂ / 24 h / Ambient temperature

With thionyl chloride; sulfuric acid; potassium chloride; ammonium chloride; sodium nitrite; In ammonium hydroxide;

DOI:10.1248/cpb.37.280

upstream raw materials:

ethanol

(R)-2-chloro-4-phenylbutanoic acid

3-phenyl-propionaldehyde

5-phenylethyl-imidazolidine-2,4-dione