4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide

Base Information

• Chemical Name: 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide
• CAS No.: 76664-75-0
• Molecular Formula: C₁₇H₁₇NO₅S₂
• Molecular Weight: 379.458
• Mol file: 76664-75-0.mol

Synonyms:

Chemical Property of 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide

There total 6 articles about 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-methyl-2-p-tolylsulphonyl-2,3-dihydro-1,2-benzothiazepin-5(4H)-one (74328-44-2) → 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1-oxide (76664-74-9) + 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide (76664-75-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 24h; Ambient temperature;

Reference yield:

2,2-dimethyl-3-oxo-2,3-dihydrobenzothiophen 1,1-dioxide (22710-93-6) → 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide (76664-75-0)

Guidance literature:

Multi-step reaction with 6 steps

1: LiAlH₄ / diethyl ether; benzene / 5 h / 25 °C

2: (CH₃CO)2O / dimethylsulfoxide / 18 h / Ambient temperature

3: 68 percent / CH₃COOH / methanol / 0.83 h

4: benzene / 1 h / Heating

5: 100 percent / Et₃N / CHCl₃ / 1 h / Ambient temperature

6: 56 percent / m-chloroperbenzoic acid / CHCl₃ / 24 h / Ambient temperature

With lithium aluminium tetrahydride; acetic anhydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; chloroform; dimethyl sulfoxide; benzene;

Reference yield:

2,2-dimethylbenzothiophen-3(2H)-one (74328-45-3) → 4-methyl-5-oxo-2-p-tolylsulphonyl-2,3,4,5-tetrahydro-1,2-benzothiazepine 1,1-dioxide (76664-75-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / CH₃COOH / methanol / 0.83 h

2: benzene / 1 h / Heating

3: 100 percent / Et₃N / CHCl₃ / 1 h / Ambient temperature

4: 56 percent / m-chloroperbenzoic acid / CHCl₃ / 24 h / Ambient temperature

With acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; benzene;

upstream raw materials:

4-methyl-2-p-tolylsulphonyl-2,3-dihydro-1,2-benzothiazepin-5(4H)-one

2,2-dimethyl-3-oxo-2,3-dihydrobenzothiophen 1,1-dioxide

2,2-dimethylbenzothiophen-3(2H)-one

4-Methyl-N-[2-(2-methyl-acryloyl)-phenylsulfanyl]-benzenesulfonamide