2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile

Base Information

• Chemical Name: 2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile
• CAS No.: 946834-57-7
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.45
• Mol file: 946834-57-7.mol

Synonyms:

Chemical Property of 2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile

There total 1 articles about 2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoquinoline (119-65-3) + trimethylsilyl cyanide (7677-24-9) + (+)-(1S,2R,5S)-menthylchloroformate (7635-54-3,7635-53-2) → 2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile (946834-57-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jo070786k

Reference yield:

2-d-menthoxycarbonyl-1,2-dihydroisoquinaldonitrile (946834-57-7) + pivalaldehyde (630-19-3) → (R)-1-isoquinolyl tert-butyl carbinyl menthyl carbonate + (S)-1-isoquinolyl tert-butyl carbinyl menthyl carbonate

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at -40 ℃; for 5h;

DOI:10.1021/jo070786k

upstream raw materials:

isoquinoline

trimethylsilyl cyanide

(+)-(1S,2R,5S)-menthylchloroformate