2-ethyl-4,5-dimethoxy-benzoic acid

Base Information

• Chemical Name: 2-ethyl-4,5-dimethoxy-benzoic acid
• CAS No.: 56183-33-6
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol file: 56183-33-6.mol

Synonyms:

Chemical Property of 2-ethyl-4,5-dimethoxy-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-4,5-dimethoxy-benzoic acid

There total 16 articles about 2-ethyl-4,5-dimethoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethyl-4,5-dimethoxy-benzaldehyde (80067-55-6) → 2-ethyl-4,5-dimethoxy-benzoic acid (56183-33-6)

Guidance literature:

With permanganate(VII) ion;

Reference yield:

2-ethenyl-4,5-dimethoxybenzaldehyde (52095-39-3) → 2-ethyl-4,5-dimethoxy-benzoic acid (56183-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 25 °C

2: sodium chlorite; sodium dihydrogen phosphate monohydrate / tert-butyl alcohol / 20 °C

With sodium chlorite; sodium dihydrogen phosphate monohydrate; palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; tert-butyl alcohol;

DOI:10.1021/acs.orglett.0c02008

Reference yield:

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) → 2-ethyl-4,5-dimethoxy-benzoic acid (56183-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; palladium diacetate; caesium carbonate / water; tetrahydrofuran / 65 °C / Inert atmosphere; Sealed tube

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 25 °C

3: sodium chlorite; sodium dihydrogen phosphate monohydrate / tert-butyl alcohol / 20 °C

With sodium chlorite; sodium dihydrogen phosphate monohydrate; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; water; ethyl acetate; tert-butyl alcohol;

DOI:10.1021/acs.orglett.0c02008

upstream raw materials:

1-(2-ethyl-4,5-dimethoxyphenyl)-1-ethanone

2-ethyl-4,5-dimethoxy-benzaldehyde

4,5-dimethoxy-2-vinylbenzoic acid

diethyl ether

Downstream raw materials:

m-hemipinic acid