Technology Process of 4-methylcoumarin-7-oxymethyl 6-(4-sulfamoylbenzamido)hexanoate
There total 4 articles about 4-methylcoumarin-7-oxymethyl 6-(4-sulfamoylbenzamido)hexanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(aminosulfonyl)-benzoic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
for 0.333333h;
Inert atmosphere;
4-methylcoumarin-7-oxymethyl 6-aminohexanoate;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ja301204z
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium azide / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere
2.1: 18-crown-6 ether; potassium carbonate / acetone / 1 h / Inert atmosphere; Reflux
2.2: 18 h / Reflux; Inert atmosphere
3.1: triphenylphosphine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
3.2: 5 h / 50 °C
4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere
4.2: 12 h / 50 °C / Inert atmosphere
With
sodium azide; 18-crown-6 ether; potassium carbonate; triphenylphosphine; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja301204z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 18-crown-6 ether; potassium carbonate / acetone / 1 h / Inert atmosphere; Reflux
1.2: 18 h / Reflux; Inert atmosphere
2.1: triphenylphosphine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
2.2: 5 h / 50 °C
3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere
3.2: 12 h / 50 °C / Inert atmosphere
With
18-crown-6 ether; potassium carbonate; triphenylphosphine; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja301204z
