(8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

Base Information

Chemical Name:(8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide
CAS No.:1211401-27-2
Molecular Formula:C₂₅H₂₅Cl₂N₅O₄
Molecular Weight:530.411
Hs Code.:

(8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

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Chemical Property of (8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

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Technology Process of (8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

There total 7 articles about (8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1211399-88-0
1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate

: 1211401-27-2
(8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 2 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.06.023

Reference yield:

: 220241-67-8
C₄H₆O₆*C₉H₁₁N

: 1211401-27-2
(8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / diethyl ether; water

2: sodium hydrogencarbonate / dichloromethane; water

3: dichloromethane / 1 h

4: hydrogenchloride / 1,4-dioxane; water / 2 h

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; diethyl ether; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.06.023

Reference yield:

: 3721-28-6
(1S,2R)-tranylcypromine

: 1211401-27-2
(8aS)-N-{2,6-dichloro-4-[(dimethylamino)carbonyl]phenyl}-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / dichloromethane; water

2: dichloromethane / 1 h

3: hydrogenchloride / 1,4-dioxane; water / 2 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.06.023