Linezolid Related Impurity 1

Base Information

• Chemical Name: Linezolid Related Impurity 1
• CAS No.: 1532560-87-4
• Molecular Formula: C₁₃H₂₀FN₃O₂
• Molecular Weight: 269.319
• Mol file: 1532560-87-4.mol

Synonyms:

Chemical Property of Linezolid Related Impurity 1

Chemical Property:

• Boiling Point: 503.2±50.0 °C(Predicted)
• PKA: 12.31±0.35(Predicted)
• Density: 1.276±0.06 g/cm3(Predicted)

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Linezolid Related Impurity 1

There total 7 articles about Linezolid Related Impurity 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline (874340-08-6) → (S)-N-(3-amino-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline (1532560-87-4,333753-72-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 2h; Solvent; Temperature;

Reference yield: 93.6%

(dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline (1260086-02-9) → (dl)-N-(3-amino-2-hydroxypropyl)-3-fluoro-4-morpholinylaniline (1532560-87-4,333753-72-3)

Guidance literature:

With ammonium hydroxide; potassium carbonate; In deuteromethanol; at 20 ℃; for 12h;

Reference yield: 91.0%

N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline (868405-66-7) → (S)-N-(3-amino-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline (1532560-87-4,333753-72-3)

Guidance literature:

With ammonium hydroxide; lithium tert-butoxide; In methanol; at 20 ℃; for 12h;

upstream raw materials:

N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline

3-fluoro-4-(morpholinyl)aniline

N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline

(dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline

Downstream raw materials:

linezolid

linezolid