4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester
• CAS No.: 267888-98-2
• Molecular Formula: C₂₉H₅₁NO₄SSi₂
• Molecular Weight: 565.965

Synonyms:

Chemical Property of 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester

There total 9 articles about 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-hydroxy-phenyl)-acetic acid ethyl ester (17138-28-2) → 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester (267888-98-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: K₂CO₃ / dimethylformamide

2.1: NaOH / H₂O; methanol

3.1: DCC; HOBt

4.1: LAH

5.1: 82 percent / n-BuLi

6.1: 51 percent / LDA

7.1: H₂ / Pd/C

7.2: ethyl acetate / reflux

8.1: DMAP

9.1: P₄S₁₀; NaHCO₃

With dmap; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; tetraphosphorus decasulfide; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Hydrolysis / 3.1: Acylation / 4.1: Reduction / 5.1: Addition / 6.1: Addition / 6.2: Addition / 7.1: Hydrogenolysis / 7.2: Cyclization / 8.1: silylation / 9.1: sulfuration;

DOI:10.1016/S0040-4039(00)00096-4

Reference yield:

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester (56441-69-1) → 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester (267888-98-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaOH / H₂O; methanol

2.1: DCC; HOBt

3.1: LAH

4.1: 82 percent / n-BuLi

5.1: 51 percent / LDA

6.1: H₂ / Pd/C

6.2: ethyl acetate / reflux

7.1: DMAP

8.1: P₄S₁₀; NaHCO₃

With dmap; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; tetraphosphorus decasulfide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; water; 1.1: Hydrolysis / 2.1: Acylation / 3.1: Reduction / 4.1: Addition / 5.1: Addition / 5.2: Addition / 6.1: Hydrogenolysis / 6.2: Cyclization / 7.1: silylation / 8.1: sulfuration;

DOI:10.1016/S0040-4039(00)00096-4

Reference yield:

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) → 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester (267888-98-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: DCC; HOBt

2.1: LAH

3.1: 82 percent / n-BuLi

4.1: 51 percent / LDA

5.1: H₂ / Pd/C

5.2: ethyl acetate / reflux

6.1: DMAP

7.1: P₄S₁₀; NaHCO₃

With dmap; lithium aluminium tetrahydride; n-butyllithium; tetraphosphorus decasulfide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; 1.1: Acylation / 2.1: Reduction / 3.1: Addition / 4.1: Addition / 4.2: Addition / 5.1: Hydrogenolysis / 5.2: Cyclization / 6.1: silylation / 7.1: sulfuration;

DOI:10.1016/S0040-4039(00)00096-4

upstream raw materials:

2-[4-(benzyloxy)benzyl]acetic acid

(4-hydroxy-phenyl)-acetic acid ethyl ester

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

tert-butyldimethylsilyl chloride

Downstream raw materials:

(2S,3S,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-5-[2-oxo-octadec-(E)-ylidene]-2-propyl-pyrrolidine-3-carboxylic acid methyl ester

(2S,3R,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester

(2S,3S,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester

(2S,3S,4R)-plakoridine A

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 267888-98-2 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send