C₂₆H₃₀F₂N₂O₆

Base Information

• Chemical Name: C₂₆H₃₀F₂N₂O₆
• CAS No.: 1351767-75-3
• Molecular Formula: C₂₆H₃₀F₂N₂O₆
• Molecular Weight: 504.531
• Mol file: 1351767-75-3.mol

Synonyms:

Chemical Property of C₂₆H₃₀F₂N₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₀F₂N₂O₆

There total 7 articles about C₂₆H₃₀F₂N₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-methoxy-1H-indol-1-yl)acetic acid (885524-81-2) + C15H21F2NO4 (1338471-24-1) → C26H30F2N2O6 (1351767-75-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

C13H15NO3 (885524-85-6) → C26H30F2N2O6 (1351767-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

C23H25F2NO6 (166388-89-2) → C26H30F2N2O6 (1351767-75-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

5-methoxylindole

2-(5-methoxy-1H-indol-1-yl)acetic acid

C₁₅H₂₁F₂NO₄

C₁₃H₁₅NO₃

Downstream raw materials:

C₂₆H₂₈F₂N₂O₆

(S)-5-(2,6-difluorophenoxy)-3-(2-(5-methoxy-1H-indol-1-yl)acetamido)-4-oxopentanoic acid