1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea

Base Information

• Chemical Name: 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea
• CAS No.: 105192-10-7
• Molecular Formula: C₂₂H₁₈N₆O₃S
• Molecular Weight: 446.489
• Mol file: 105192-10-7.mol

Synonyms:

Chemical Property of 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea

There total 3 articles about 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(4-methoxyphenylmethylene)malononitrile (2826-26-8) + cyanoacetic acid 2'-[(benzoylamino)thiocarbonyl]hydrazide (54779-96-3) → 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea (105192-10-7)

Guidance literature:

With triethylamine; In ethanol; for 1h; Ambient temperature;

Reference yield:

Benzoyl isothiocyanate (532-55-8) → 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea (105192-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetone / 2 h / Heating

2: 60 percent / NEt₃ / ethanol / 1 h / Ambient temperature

With triethylamine; In ethanol; acetone;

Reference yield:

1,4-Diamino-6-imino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-oxo-1,2,5,6-tetrahydro-pyridine-3-carbonitrile (94829-43-3) + Benzoyl isothiocyanate (532-55-8) → 1-{4-Amino-5-cyano-2-imino-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-oxo-3,6-dihydro-2H-pyridin-1-yl}-3-benzoyl-thiourea (105192-10-7)

Guidance literature:

In acetone; for 2h; Heating;

upstream raw materials:

2-(4-methoxyphenylmethylene)malononitrile

cyanoacetic acid 2'-[(benzoylamino)thiocarbonyl]hydrazide

1,4-Diamino-6-imino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-oxo-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

Benzoyl isothiocyanate