(1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride

Base Information

Chemical Name:(1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride
CAS No.:1401074-84-7
Molecular Formula:C₂₃H₂₅N₃O₂*ClH
Molecular Weight:411.931
Hs Code.:

Synonyms:

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Chemical Property of (1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride

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Technology Process of (1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride

There total 4 articles about (1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1401074-84-7
(1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 50 °C

2.2: 0.17 h / 0 - 50 °C

With dimethylsulfide borane complex; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; toluene; 1.1: Buchwald Coupling;

Reference yield:

: 1400984-80-6
N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

: 1401074-84-7
(1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 50 °C

2.2: 0.17 h / 0 - 50 °C

With dimethylsulfide borane complex; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; toluene; 1.1: Buchwald Coupling;

Reference yield:

: 95-55-6
2-amino-phenol

: 1401074-84-7
(1R)-1-(3-methoxyphenyl)-N-((4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]yl)methyl)ethanamine monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 15 h / 45 °C

2.1: trimethylaluminum / toluene / 0.25 h / 50 °C / Inert atmosphere

2.2: 5 h / 110 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

4.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 50 °C

4.2: 0.17 h / 0 - 50 °C

With dimethylsulfide borane complex; trimethylaluminum; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3.1: Buchwald Coupling;