(RS,SR) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride

Base Information

• Chemical Name: (RS,SR) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride
• CAS No.: 133534-75-5
• Molecular Formula: C₂₀H₂₅NO₄*ClH
• Molecular Weight: 379.884
• Mol file: 133534-75-5.mol

Synonyms:

Chemical Property of (RS,SR) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS,SR) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride

There total 14 articles about (RS,SR) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

ethanol (64-17-5) + (RS,RS) 2-methoxy-3-(2-ethoxyphenoxy)-benzenepropanenitrile (133534-63-1,133534-66-4) → (RS,SR) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride (133534-75-5,133534-76-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 7h; Ambient temperature;

DOI:10.1016/0223-5234(90)90195-9

Reference yield: 76.4%

ethanol (64-17-5) + (RS,SR) 2-methoxy-3-(2-ethoxyphenoxy)-benzenepropanenitrile (133534-63-1,133534-66-4) → (RS,RS) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride (133534-75-5,133534-76-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 7h; Ambient temperature;

DOI:10.1016/0223-5234(90)90195-9

Reference yield:

2-Ethoxyphenol (94-71-3) → (RS,RS) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride (133534-75-5,133534-76-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 57.2 percent / 85percent aq. KOH / 7 h / 70 °C

2: 100 percent / 98percent H₂SO₄ / 40 h / Ambient temperature

3: 100 percent / NaH / dimethylformamide / 1 h / 10 °C

4: 77.4 percent / 30percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

5: 87.6 percent / pyridine, trifluoroacetic anhydride / dioxane / 3 h / Ambient temperature

6: 76.4 percent / HCl (gas) / diethyl ether / 7 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; ammonium hydroxide; sulfuric acid; sodium hydride; trifluoroacetic anhydride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(90)90195-9

upstream raw materials:

ethanol

(RS,SR) 2-methoxy-3-(2-ethoxyphenoxy)-benzenepropanenitrile

2-Ethoxyphenol

(RS,RS) 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanoic acid

Downstream raw materials:

(RS,SR) 1-ethyl-2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole

(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole

(RS,RS) 1-ethyl-2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole