2-(4-CHLOROPHENOXY)NICOTINIC ACID

Base Information

• Chemical Name: 2-(4-CHLOROPHENOXY)NICOTINIC ACID
• CAS No.: 51362-37-9
• Molecular Formula: C12H8 Cl N O3
• Molecular Weight: 249.653
• Hs Code.: 2933399090
• Mol file: 51362-37-9.mol

Synonyms:2-(4-Chlorophenoxy)-3-pyridinecarboxylicacid; 2-(4-Chlorophenoxy)nicotinic acid; 2-(p-Chlorophenoxy)nicotinic acid

Chemical Property of 2-(4-CHLOROPHENOXY)NICOTINIC ACID

Chemical Property:

• Vapor Pressure: 5.29E-07mmHg at 25°C
• Melting Point: 157-159°C
• Boiling Point: 396.6°Cat760mmHg
• PKA: 2.56±0.36(Predicted)
• Flash Point: 193.7°C
• PSA: 59.42000
• Density: 1.404g/cm³
• LogP: 3.22550

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-Chlorophenoxy)nicotinic acid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CHLOROPHENOXY)NICOTINIC ACID

There total 3 articles about 2-(4-CHLOROPHENOXY)NICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

2-chloronicotinic acid (2942-59-8) + 4-chloro-phenol (106-48-9,82344-39-6) → 2-(4-chlorophenoxy)nicotinic acid (51362-37-9)

Guidance literature:

With copper; potassium carbonate; In butan-1-ol; at 130 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.6b00316

Reference yield:

2-chloronicotinic acid (2942-59-8) + sodium 4-chlorophenolate (1193-00-6) → 2-(4-chlorophenoxy)nicotinic acid (51362-37-9)

Guidance literature:

DOI:10.1124/mol.105.017384

Reference yield:

→ 2-(4-chlorophenoxy)nicotinic acid (51362-37-9)

Guidance literature:

p-Chlorphenol, 2-Chlornicotinsaeure;

DOI:10.1007/BF00480398

upstream raw materials:

2-chloronicotinic acid

sodium 4-chlorophenolate

4-chloro-phenol

Downstream raw materials:

C₂₄H₂₃ClN₂O₅

2-[(4-chlorophenyl)oxy]-N-[(1R)-2-(4-methylpiperazin-1-yl)-2-oxo-1-{[(phenylmethyl)amino]methyl}ethyl]pyridine-3-carboxamide

2-[(4-chlorophenyl)oxy]-N-[(1R)-1-({[(3-methylphenyl)methyl]oxy}-methyl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyridine-3-carboxamide

2-(4-chlorophenoxy)nicotinoyl chloride

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