NH(Bzl)-Ser(tBu)-Met-NH-tBu

Base Information

• Chemical Name: NH(Bzl)-Ser(tBu)-Met-NH-tBu
• CAS No.: 616237-93-5
• Molecular Formula: C₂₃H₃₉N₃O₃S
• Molecular Weight: 437.647
• Mol file: 616237-93-5.mol

Synonyms:

Chemical Property of NH(Bzl)-Ser(tBu)-Met-NH-tBu

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NH(Bzl)-Ser(tBu)-Met-NH-tBu

There total 3 articles about NH(Bzl)-Ser(tBu)-Met-NH-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzaldehyde (100-52-7) + H-Ser(tBu)-Met-NH-tBu → NH(Bzl)-Ser(tBu)-Met-NH-tBu (616237-93-5) + N(Bzl)2-Ser(tBu)-Met-NH-tBu (616237-94-6)

Guidance literature:

With sodium cyanoborohydride; In acetonitrile; for 0.25h;

DOI:10.1016/S0968-0896(02)00563-1

Reference yield:

Fmoc-Ser(tBu)-OH (71989-33-8) → NH(Bzl)-Ser(tBu)-Met-NH-tBu (616237-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine; HOBt; WSC / dimethylformamide / 19 h / 0 - 20 °C

2: piperidine / dimethylformamide / 0.42 h

3: 70 percent / NaCNBH₃ / acetonitrile / 0.25 h

With piperidine; 4-methyl-morpholine; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0968-0896(02)00563-1

Reference yield:

H-Met-NH-tBu → NH(Bzl)-Ser(tBu)-Met-NH-tBu (616237-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine; HOBt; WSC / dimethylformamide / 19 h / 0 - 20 °C

2: piperidine / dimethylformamide / 0.42 h

3: 70 percent / NaCNBH₃ / acetonitrile / 0.25 h

With piperidine; 4-methyl-morpholine; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0968-0896(02)00563-1

upstream raw materials:

benzaldehyde

Fmoc-Ser(tBu)-OH